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(18)F-labeled phenyldiazenyl benzothiazole for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains

ACS Medicinal Chemistry Letters

Jan 12, 2012

Kenji MatsumuraHideo Saji

Abstract

We synthesized and evaluated (E)-4-((6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzo[d]thiazol-2-yl)diazenyl)-N,N-dimethylaniline (FPPDB) as a probe for the imaging of neurofibrillary tangles (NFTs) in patients with Alzheimer's disease (AD). In assays using thioflavin S (ThS) as a competiti...read more

Mentioned in this Paper

Benzothiazole [EPC]
Neurofibrillary Degeneration (Morphologic Abnormality)
Brain
Uptake
Alzheimer's Disease
Diffuse Neurofibrillary Tangles With Calcification
Senile Plaques
In Vivo Imaging
Ligands Activity
Thioflavin S
1
37
Paper Details
References

(18)F-labeled phenyldiazenyl benzothiazole for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains

ACS Medicinal Chemistry Letters

Jan 12, 2012

Kenji MatsumuraHideo Saji

PMID: 24900371

DOI: 10.1021/ml200230e

Abstract

We synthesized and evaluated (E)-4-((6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzo[d]thiazol-2-yl)diazenyl)-N,N-dimethylaniline (FPPDB) as a probe for the imaging of neurofibrillary tangles (NFTs) in patients with Alzheimer's disease (AD). In assays using thioflavin S (ThS) as a competiti...read more

Mentioned in this Paper

Benzothiazole [EPC]
Neurofibrillary Degeneration (Morphologic Abnormality)
Brain
Uptake
Alzheimer's Disease
Diffuse Neurofibrillary Tangles With Calcification
Senile Plaques
In Vivo Imaging
Ligands Activity
Thioflavin S
1
37

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