18F]Ciprofloxacin, a new positron emission tomography tracer for noninvasive assessment of the tissue distribution and pharmacokinetics of ciprofloxacin in humans

Antimicrobial Agents and Chemotherapy
Martin BrunnerMarkus Müller

Abstract

The biodistribution and pharmacokinetics of the fluorine-18-labeled fluoroquinolone antibiotic [(18)F]ciprofloxacin in tissue were studied noninvasively in humans by means of positron emission tomography (PET). Special attention was paid to characterizing the distribution of [(18)F]ciprofloxacin to select target tissues. Healthy volunteers (n = 12) were orally pretreated for 5 days with therapeutic doses of unlabeled ciprofloxacin. On day 6, subjects received a tracer dose (mean injected amount, 700 +/- 55 MBq, which contained about 0.6 mg of unlabeled ciprofloxacin) of [(18)F]ciprofloxacin as an intravenous bolus. Thereafter, PET imaging and venous blood sampling were initiated. Time-radioactivity curves were measured for liver, kidney, lung, heart, spleen, skeletal muscle, and brain tissues for up to 6 h after radiotracer administration. The first application of [(18)F]ciprofloxacin in humans has demonstrated the safety and utility of the newly developed radiotracer for pharmacokinetic PET imaging of the tissue ciprofloxacin distribution. Two different tissue compartments of radiotracer distribution could be identified. The first compartment including the kidney, heart, and spleen, from which the radiotracer was washed out re...Continue Reading

References

Nov 1, 1991·Antimicrobial Agents and Chemotherapy·R GarraffoP Lapalus
Oct 1, 1993·Antimicrobial Agents and Chemotherapy·A J FischmanH W Strauss
Dec 1, 1995·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P Ball, G Tillotson
Aug 1, 1996·Nuclear Medicine and Biology·T J TewsonP Frank
Jan 9, 1998·Drug Metabolism Reviews·A J FischmanR H Rubin
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·A J FischmanR H Rubin
Sep 28, 1998·Biochimica Et Biophysica Acta·D C Hooper
May 1, 1999·Antimicrobial Agents and Chemotherapy·M BrunnerM Müller
May 4, 1999·The Journal of Antimicrobial Chemotherapy·M C BirminghamJ J Schentag
Oct 30, 1999·Antimicrobial Agents and Chemotherapy·J D WaltersR J Nakkula
Dec 5, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·E C de LangeW Couet
Oct 3, 2002·The Journal of Antimicrobial Chemotherapy·Marc LeoneClaude Martin
Oct 29, 2002·Journal of Clinical Pathology·K E BrittonA K Padhy
Nov 19, 2002·Antimicrobial Agents and Chemotherapy·Martin BrunnerMarkus Müller
May 15, 2003·Nuclear Medicine and Biology·Oliver LangerMarkus Müller
Jun 7, 2003·International Journal of Antimicrobial Agents·J A A Hoogkamp-KorstanjeUNKNOWN Susceptibility Surveillance Study Group
Aug 26, 2003·European Journal of Clinical Pharmacology·Mats BergströmBengt Långström
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Markus MüllerHartmut Derendorf

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Citations

Feb 4, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Oliver LangerMarkus Müller
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Rainer GattringerChristian Joukhadar
Mar 20, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Prabodh Chander SharmaMohammad Shahar Yar
Oct 5, 2010·Advanced Drug Delivery Reviews·Claudia C Wagner, Oliver Langer
Nov 29, 2008·Seminars in Nuclear Medicine·Filip GemmelMick Welling
Sep 19, 2015·Drug Testing and Analysis·Adeola ShoboThavendran Govender
Jul 8, 2016·Journal of Clinical Pharmacology·Oliver Langer
Aug 12, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·S AulettaAlberto Signore
Jul 14, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·M P ChrysouliS K Hadjikakou
Nov 23, 2019·International Journal of Molecular Sciences·Justin D NorthrupMark A Sellmyer
Dec 5, 2019·International Journal of Molecular Sciences·Camilo A Ruiz-BedoyaSanjay K Jain
Jul 6, 2018·Molecular Biology Reports·Syed Ali Raza NaqviMuhammad Imran
Apr 19, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Irene Hernández-LozanoOliver Langer

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