18F]fluorodeoxyglucose uptake in neonatal acute lung injury measured by positron emission tomography

Pediatric Research
H KirpalaniB Schmidt

Abstract

The objective of this study was to evaluate positron emission tomography (PET) of [18F]fluorodexoyglucose (18FDG) uptake as a measure of neonatal acute lung injury. Inasmuch as intrapulmonary sequestration of neutrophils is a hallmark of acute lung injury, quantification of neutrophil activity using 18FDG may offer a novel, in vivo technique to examine the progression and resolution of this disease. Ten newborn piglets were studied: six received bronchoalveolar lavage followed by 4 h of high pressure ventilation of create acute lung injury. Four healthy piglets served as controls. 18FDG (0.8 mCi/kg; 29.6 MBq) was given i.v. and PET (ECAT 953/31, Siemens) was performed for 90 min. During PET, all animals were sedated, paralyzed, and ventilated to maintain normal blood gases. The time course of radioactivity in lung regions and in plasma was used to calculate the rate constant for the metabolic trapping of 18FDG in tissue according to the method of C. S. Patlak. Median 18FDG influx constants were significantly higher in injured piglets (0.0187 min-1) than in control piglets (0.0052 min-1) (p < 0.01). Moreover, consistent with the 18FDG uptake data, injured piglets had moderate to severe injury on lung histology whereas control pi...Continue Reading

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Citations

Jun 27, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M B Dolovich
Nov 17, 2004·Clinical Nuclear Medicine·Heather A JaceneRichard L Wahl
Jul 27, 2005·Inflammatory Bowel Diseases·Daniel A LembergKevan Jacobson
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Jun 28, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zhaohui ZhouDaniel P Schuster
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Nov 24, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel P SchusterMichael Mueckler
Sep 28, 2002·Critical Care Medicine·Lena M Napolitano

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