18F]fluoromisonidazole and a new PET system with semiconductor detectors and a depth of interaction system for intensity modulated radiation therapy for nasopharyngeal cancer

International Journal of Radiation Oncology, Biology, Physics
Koichi YasudaHiroki Shirato

Abstract

The impact of a new type of positron emission tomography (New PET) with semiconductor detectors using 18F-labeled fluoromisonidazole (FMISO)-guided intensity modulated radiation therapy (IMRT) was compared with a state-of-the-art PET/computed tomography (PET/CT) system in nasopharyngeal cancer (NPC) patients. Twenty-four patients with non-NPC malignant tumors (control group) and 16 patients with NPC were subjected to FMISO-PET. The threshold of the tumor-to-muscle (T/M) ratio in each PET scan was calculated. The hypoxic volume within the gross tumor volume (GTVh) was determined using each PET (NewPETGTVh and PET/CTGTVh, respectively). Dose escalation IMRT plans prescribing 84 Gy to each GTVh were carried out. The threshold of the T/M ratio was 1.35 for New PET and 1.23 for PET/CT. The mean volume of NewPETGTVh was significantly smaller than that of PET/CTGTVh (1.5±1.6 cc vs 4.7±4.6 cc, respectively; P=.0020). The dose escalation IMRT plans using New PET were superior in dose distribution to those using PET/CT. Dose escalation was possible in all 10 New PET-guided plans but not in 1 PET/CT-guided plan, because the threshold dose to the brainstem was exceeded. New PET was found to be useful for accurate dose escalation in FMISO-g...Continue Reading

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Citations

Nov 19, 2015·International Journal of Clinical Oncology·Nagara Tamaki, Kenji Hirata
Apr 2, 2015·PET Clinics·Minh Tam Truong, Nataliya Kovalchuk
Oct 19, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Takuya ToyonagaNagara Tamaki
Jul 7, 2017·Clinical Nuclear Medicine·Tohru ShigaNagara Tamaki
Jan 22, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mitsue KawamuraMasahiro Hiraoka
Jan 17, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shozo OkamotoNagara Tamaki

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