PMID: 6310235Jul 1, 1983

19-Hydroxyandrostenedione: a potent hypertensinogenic steroid in man

Journal of Steroid Biochemistry
H Sekihara

Abstract

The hypertensinogenic effects of 19-hydroxyandrostenedione (19-OH-A-dione), which we reported as an amplifier of the action of aldosterone on the basis of the results obtained in bioassays using adrenalectomized rats, were evaluated in intact rats with both adrenals and kidneys. The administration of 19-OH-A-dione to the rats caused sodium retention and the 19-OH-A-dione treated rats developed high blood pressure, suppressed plasma renin activity and low plasma aldosterone, corticosterone and deoxycorticosterone concentrations. The hypertensinogenic potency of 19-OH-A-dione was incomparably higher than that of DOCA. The results indicate that 19-OH-A-dione is a potent hypertensinogenic steroid and causes the hypertensive state similar to mineralocorticoid excess. The evaluation of 19-OH-A-dione concentrations in human plasma revealed that 19-OH-A-dione is present in human peripheral circulation. It appears to be secreted by the adrenal cortex under the control of ACTH and the renin-angiotensin system. Plasma 19-OH-A-dione concentrations in patients with normal renin essential hypertension and low renin essential hypertension are higher than those in control subjects. 19-OH-A-dione is a newly recognised hypertensinogenic steroid ...Continue Reading

Citations

Mar 24, 1995·Pharmacy World & Science : PWS·W Sutanto, E R de Kloet
Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·H MuraseK Miura
Jul 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J I RaesideD E Marshall
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·C Tosti-CroceF Sciarra

Related Concepts

19-hydroxy-4-androstene-3,17-dione, 18O-labeled
Corticotropin
Androstenedione
Angiotensin II, Val(5)-
Diastolic Blood Pressure
Deoxycorticosterone
Oradexon
Potassium
Sodium

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