PMID: 7129814Jul 1, 1982Paper

1982 Memorial Award Paper. Detection of regional myocardial dysfunction during ischemia with computerized tomography: documentation and physiologic basis

Investigative Radiology
R F Mattrey, C B Higgins


Cross-sectional imaging techniques have the potential for measuring left ventricular (LV) wall thickness (WTh) dynamics. This proposition was assessed in a canine experimental model, using prospectively gated computed tomography (CT) scans before and after occlusion of a coronary artery. Gated CT scans detected loss of wall thickening in the LV anterior segment immediately after occlusion of the left anterior descending coronary artery in two dogs. After demonstrating the feasibility of using gated CT scans to demonstrate ischemic functional abnormalities by monitoring wall thickness changes, we assessed the relationship between regional wall thickening dynamics and coronary blood flow in eight anesthetized dogs. Graded circumflex (Cx) coronary artery stenosis (CAS) was produced while sonomicrometer crystals continuously recorded LV WTh and extent of wall thickening (EWTh) in the anterior descending and the Cx distributions. The first significant change in EWTh in the ischemic segment occurred at 33% decrease in CBF (P less than .05) which corresponded to an 80% CAS. At 33% decrease in CBF, there was a concomitant increase in EWTh in the normal segment. In conclusion, we have demonstrated the feasibility of using gated CT to de...Continue Reading


Jan 1, 1985·International Journal of Cardiac Imaging·J S GarrettM J Lipton
Oct 21, 2011·Radiology·Karen G Ordovas, Charles B Higgins
Mar 1, 1988·Progress in Cardiovascular Diseases·F R Cobb, A Chu
Feb 1, 1985·International Journal of Cardiology·B H Brundage, D Spigos

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