1995 AUR Memorial Award. Gamma knife irradiation-induced changes in the normal rat brain studied with 1H magnetic resonance spectroscopy and imaging

Academic Radiology
R A OmaryB J Hillman

Abstract

The pathogenesis of brain injury following radiosurgery is poorly understood. To better elucidate the relationship between blood-brain barrier disruption and metabolic derangements, we used magnetic resonance (MR) imaging and 1H MR spectroscopy to detect early changes from focused single-fraction, high-dose irradiation injury in rat brains. Using the Leksell gamma knife, we irradiated the frontoparietal cortex of 11 male Wistar rats with a single dose of 120 Gy. Four weeks later, we sequentially performed water-suppressed 1H MR spectroscopy and gadopentetate dimeglumine-enhanced T1-weighted MR imaging. Metabolic maps were created of n-acetylaspartate (NAA), creatine and choline (Cr/Cho), and lactate from the MR spectroscopy data set. Detection of irradiation injury among the tested modalities was assessed by receiver operating characteristic analysis and by quantitative signal intensity changes. Pathologic confirmation of irradiation damage was obtained in all rats. Gadopentetate dimeglumine-enhanced T1-weighted MR imaging was the only imaging modality that detected statistically significant signal intensity changes (p < .05). No reproducible changes in the metabolites of interest could be detected by 1H MR spectroscopy. In our...Continue Reading

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Citations

Sep 7, 2004·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Simmons Lessell
Jan 31, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Amina Malik, Karl Golnik
Jul 5, 2007·Neurosurgical Focus·Kaveh BaramiAndrew E Sloan
Dec 19, 2009·Radiology·Yi-Xiang J WangAnil T Ahuja
Jun 8, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jean Régis
Dec 11, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Helen V Danesh-Meyer
Aug 11, 2006·Stereotactic and Functional Neurosurgery·J D RabinovR G Gonzalez
Oct 23, 2004·Stereotactic and Functional Neurosurgery·James D RabinovR Gilberto Gonzalez
Jun 1, 2010·Journal of Neuro-oncology·Jean RégisMichael Park
Jul 2, 2021·Neuro-ophthalmology·Fabrício Gomes AtaídesJulianna Joanna Carvalho Moraes De Campos Baldin

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