19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement

Magnetic Resonance Imaging
Atsuomi KimuraHideaki Fujiwara

Abstract

The tissue distribution of perfluorooctanoic acid (PFOA), which is known to show unique biological responses, has been visualized in female mice by (19)F magnetic resonance imaging (MRI) incorporated with the recent advances in microimaging technique. The chemical shift selected fast spin-echo method was applied to acquire in vivo (19)F MR images of PFOA. The in vivo T(1) and T(2) relaxation times of PFOA were proven to be extremely short, which were 140 (+/- 20) ms and 6.3 (+/- 2.2) ms, respectively. To acquire the in vivo (19)F MR images of PFOA, it was necessary to optimize the parameters of signal selection and echo train length. The chemical shift selection was effectively performed by using the (19)F NMR signal of CF(3) group of PFOA without the signal overlapping because the chemical shift difference between the CF(3) and neighbor signals reaches to 14 kHz. The most optimal echo train length to obtain (19)F images efficiently was determined so that the maximum echo time (TE) value in the fast spin-echo sequence was comparable to the in vivo T(2) value. By optimizing these parameters, the in vivo (19)F MR image of PFOA was enabled to obtain efficiently in 12 minutes. As a result, the time course of the accumulation of PFO...Continue Reading

References

Jan 1, 1991·Journal of Biochemical Toxicology·J P Vanden HeuvelR E Peterson
Oct 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·H HanhijärviL Singer
Aug 1, 1980·American Industrial Hygiene Association Journal·F A UbelD E Roach
Feb 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C H SotakS Raynolds
Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R SchwarzB Künnecke
Nov 26, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·U NöthJ Lutz
Apr 20, 2001·Advanced Drug Delivery Reviews·M P Krafft
Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Simone Laukemper-OstendorfWolfgang G Schreiber
Jul 3, 2002·Toxicology·Deanna J LuebkerAndrew M Seacat
Jun 17, 2003·Chemical Research in Toxicology·Xing HanGary W Jepson
Jun 25, 2003·The Journal of Toxicological Sciences·Naomi Kudo, Yoichi Kawashima

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Citations

Nov 11, 2009·Pharmaceutical Research·Raquel Díaz-LópezElias Fattal
Dec 13, 2006·Journal of Drug Targeting·Y Bruce Yu
Nov 19, 2009·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jelena M Janjic, Eric T Ahrens
Jul 22, 2010·Contrast Media & Molecular Imaging·Maarten B KokGustav J Strijkers
Feb 7, 2017·Environmental Science & Technology·Denis Courtier-MuriasFrançois Lafolie
Apr 1, 2005·Journal of Microencapsulation
Feb 15, 2018·Scientific Reports·Eric A TanifumAnanth V Annapragada
Jun 28, 2016·ChemMedChem·Anh Minh HuynhGregor Jung
Jun 3, 2014·Journal of the American Chemical Society·Ilaria TirottaGiuseppe Resnati

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