1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis

Carcinogenesis
Bo-Ying BaoYi-Fen Lee

Abstract

Angiogenesis is an essential step in initial tumor development and metastasis. Consequently, compounds that inhibit angiogenesis would be useful in treating cancer. A variety of antitumor effects mediated by 1alpha, 25-dihydroxyvitamin D3 (1,25-VD) have been reported, one of which is anti-angiogenesis; however, detailed mechanisms remain unclear. We have demonstrated that 1,25-VD inhibits prostate cancer (PCa) cell-induced human umbilical vein endothelial cell migration and tube formation, two critical steps involved in the angiogenesis. An angiogenesis factor, interleukin-8 (IL-8), secreted from PCa cell was suppressed by 1,25-VD at both mRNA and protein levels. Mechanistic dissection found that 1,25-VD inhibits NF-kappaB signal, one of the most important IL-8 upstream regulators. The 1,25-VD-mediated NF-kappaB signal reduction was shown to result from the blocking of nuclear translocation of p65, a subunit of the NF-kappaB complex, and was followed by attenuation of the NF-kappaB complex binding to DNA. The role of IL-8 in PCa progression was further examined by PCa tissue microarray analyses. We found that IL-8 expression was elevated during PCa progression, which suggests that IL-8 may play a role in tumor progression media...Continue Reading

Citations

Jul 26, 2012·Cancer Causes & Control : CCC·Ting-Yuan David Cheng, Marian L Neuhouser
Mar 27, 2007·Nature Reviews. Cancer·Masao Matsuoka, Kuan-Teh Jeang
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson
Nov 29, 2007·Current Opinion in Gastroenterology·Stephen J D O'Keefe
Oct 5, 2011·Seminars in Dialysis·James Goya HeafPeter Marckmann
Aug 31, 2012·American Journal of Physiology. Cell Physiology·M GrundmannF von Versen-Höynck
Jan 16, 2013·Endocrine-related Cancer·Carlien LeyssensAnnemieke Verstuyf
Oct 3, 2013·Nutrients·Meis Moukayed, William B Grant
May 17, 2011·Indian Journal of Pharmacology·Chandra Kanti Chakraborti
Apr 14, 2010·Journal of Endocrinological Investigation·P ComeglioM Maggi
Jun 24, 2010·Journal des maladies vasculaires·C CormierJ-C Souberbielle
Apr 8, 2014·Nature Reviews. Cancer·David FeldmanBrian J Feldman
Jan 10, 2014·Endocrine·Daniel D Bikle
Jan 9, 2007·The Journal of Steroid Biochemistry and Molecular Biology·T C ChenA Kittaka
Mar 21, 2007·The Journal of Steroid Biochemistry and Molecular Biology·C S SpinaM F Holick
Oct 13, 2010·Annual Review of Pharmacology and Toxicology·Aruna V Krishnan, David Feldman
Oct 13, 2011·Advances in Preventive Medicine·Krishna Vanaja Donkena, Charles Y F Young
Aug 30, 2008·Wiener klinische Wochenschrift·Natalie SampsonPeter Berger
Dec 1, 2007·Advances in Anatomic Pathology·Milton W DattaMahul B Amin
Jul 12, 2011·Cellular and Molecular Life Sciences : CMLS·Hui HuaYangfu Jiang
Dec 10, 2008·Expert Opinion on Therapeutic Targets·José M ValdivielsoElvira Fernandez
Feb 17, 2009·Cancer Investigation·Jorge L YaoAlok A Khorana
Mar 5, 2016·Frontiers in Immunology·Ken BataiRick A Kittles
Apr 25, 2012·Rheumatic Diseases Clinics of North America·Aruna V KrishnanDavid Feldman
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·E VanoirbeekA Verstuyf
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Aruna V KrishnanDavid Feldman
Jul 13, 2007·The Prostate·Zoya LagunovaJohan Moan
Jan 4, 2007·The Journal of Pathology·N SampsonP Berger
Aug 6, 2010·The Prostate·Sarah K HoltJanet L Stanford
Oct 27, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heike Annette Bischoff-FerrariAndreas Egli
Feb 2, 2011·The American Journal of Pathology·Jong-Wei HsuYi-Fen Lee
Apr 9, 2016·International Journal of Molecular Sciences·Elzbieta PawlowskaJanusz Blasiak
Aug 4, 2015·Chinese Journal of Natural Medicines·Rachel A NessWei Li
Dec 16, 2011·The Biochemical Journal·James C FleetYan Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.