1alpha,25-dihydroxy-vitamin-D3 as new immunotherapy in treatment of recurrent spontaneous abortion

Medical Hypotheses
I Bubanovic

Abstract

Recurrent spontaneous abortion (RSA) is serious health problem affecting 2-5% of reproducing couples worldwide. It has long been suspected that nearly 80% of the unexplained RSAs are due to immunologic causes. Although the major tissue confronting the mother's immune system is the placental villous trophoblast, the immunological risk to the developing embryo is not great until the time of implantation. In addition, trophoblast is not sensible to lysis by NK cells, TNF-alpha or macrophages, but may be killed by lymphokine activated NK cells (LAK) and may undergo apoptosis in response to TNF-alpha and/or IFN-gamma in vitro. The two most commonly used treatments for RSA are intravenous immunoglobulin (IVIg) and alloimmunization with partner's leukocytes (LIT). We promote vitamin D3 as new immunomodulatory agent in treatment of RSA. Different mechanisms have been proposed to account for the immunosuppressive effect of 1alpha, 25-dihydroxy-vitamin-D3 (VD3). Portion of the VD3 activity involves the downregulation of IL-2, IFN-gamma and TNF-alpha genes transcription. Because immunomodulatory effects of VD3 are very similar to IL-10 effects, acting of VD3 in immunotherapy of RSA syndrome, preeclamptic and eclamptic pregnancy, as well a...Continue Reading

References

Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·D A ClarkJ F Mowbray
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·K BeamanA Gilman-Sachs
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Michael PlevyakSurendra Sharma

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Citations

May 21, 2005·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
Jul 3, 2010·The British Journal of Nutrition·Elina Hyppönen, Barbara J Boucher
Nov 10, 2009·Fertility and Sterility·Amir Hassan ZarnaniMahmood Jeddi-Tehrani
Nov 8, 2017·The Journal of Endocrinology·Ankana GangulyMartin Hewison
Sep 14, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N LiM J Li
Mar 25, 2019·American Journal of Reproductive Immunology : AJRI·Jinlu JiAihua Liao
Apr 29, 2015·Molecular Reproduction and Development·Maryam TavakoliAmir-Hassan Zarnani

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