PMID: 7529018Sep 1, 1994Paper

1C5 antigen: cancer-associated protein expressed by cervical adenocarcinomas and beta-casein

Asia-Oceania Journal of Obstetrics and Gynaecology
E HorimotoR Kudo

Abstract

The monoclonal antibody 1C5 reacts with an antigenic determinant present in 90% of the cases of adenocarcinoma of the uterine cervix. The antigen defined by the 1C5 antibody exhibits immunological characteristics similar to those of skim milk (bovine buttermilk). 1C5-defined antigen obtained from tumor extract and skim milk binds specifically to wheat germ agglutinin (WGA) lectin. The 1C5-defined antigenic activity of a WGA lectin-bound fraction was eluted at 0.7-0.8 M NaCl off a Mono Q column. Use of an inhibition assay and a dot immunobinding assay revealed that the antigenic epitope defined by the 1C5 MoAb from skim milk exists within the first 28 amino acids of the beta-casein peptide.

References

Aug 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A PichA Carbonara
Jan 1, 1990·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R KudoS G Silverberg
Apr 20, 1989·Nature·D VercelliH Gould
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B BettlerH Hofstetter
Feb 15, 1989·Analytical Biochemistry·M G ScherR J Bloch
Nov 15, 1989·Cancer·S S DevesaJ F Fraumeni
Jan 1, 1982·Analytical Biochemistry·R HawkesJ Gordon

❮ Previous
Next ❯