1D vs. 2D shape selectivity in the crystallization-driven self-assembly of polylactide block copolymers

Chemical Science
Maria InamRachel K O'Reilly

Abstract

2D materials such as graphene, LAPONITE® clays or molybdenum disulfide nanosheets are of extremely high interest to the materials community as a result of their high surface area and controllable surface properties. While several methods to access 2D inorganic materials are known, the investigation of 2D organic nanomaterials is less well developed on account of the lack of ready synthetic accessibility. Crystallization-driven self-assembly (CDSA) has become a powerful method to access a wide range of complex but precisely-defined nanostructures. The preparation of 2D structures, however, particularly those aimed towards biomedical applications, is limited, with few offering biocompatible and biodegradable characteristics as well as control over self-assembly in two dimensions. Herein, in contrast to conventional self-assembly rules, we show that the solubility of polylactide (PLLA)-based amphiphiles in alcohols results in unprecedented shape selectivity based on unimer solubility. We use log Poct analysis to drive solvent selection for the formation of large uniform 2D diamond-shaped platelets, up to several microns in size, using long, soluble coronal blocks. By contrast, less soluble PLLA-containing block copolymers yield cy...Continue Reading

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Citations

May 19, 2018·Macromolecular Rapid Communications·Kevin M BurridgeDominik Konkolewicz
Oct 20, 2018·Angewandte Chemie·Jeffrey C FosterRachel K O'Reilly
Jul 11, 2019·Angewandte Chemie·Andrea D MergVincent P Conticello
Jul 2, 2020·Macromolecular Rapid Communications·Shan MeiChristopher Y Li
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Mar 27, 2020·Chemical Communications : Chem Comm·Shaofei SongMitchell A Winnik
Aug 26, 2020·Chemistry : a European Journal·Sandra DíazJavier Montenegro
Nov 22, 2020·Nature Chemistry·Gregory I PetersonTae-Lim Choi
Dec 20, 2020·Angewandte Chemie·Jonas HeckelAndreas Walther
Mar 17, 2021·Macromolecular Rapid Communications·Xiaolin LyuZhigang Zou
Feb 25, 2021·Angewandte Chemie·Shaofei SongMitchell A Winnik
Apr 16, 2021·Journal of the American Chemical Society·Shaofei SongMitchell A Winnik
May 11, 2021·Soft Matter·Jonas HeckelAndreas Walther
Jun 25, 2021·Chemical Science·Liam MacFarlaneIan Manners
Feb 6, 2018·Journal of the American Chemical Society·Jiangping XuMitchell A Winnik
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Jul 1, 2020·Journal of the American Chemical Society·Huda ShaikhIan Manners
Aug 14, 2020·Journal of the American Chemical Society·Tomoya FukuiIan Manners
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Feb 3, 2018·ACS Central Science·Maria InamRachel K O'Reilly
Oct 29, 2017·Journal of the American Chemical Society·Maria C ArnoRachel K O'Reilly
Nov 13, 2019·Journal of the American Chemical Society·Sanghee YangTae-Lim Choi
Oct 4, 2019·Journal of the American Chemical Society·Ethan R SauvéZachary M Hudson

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Methods Mentioned

BETA
NMR
AFM
X-ray
electron diffraction

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