1,[Formula: see text]2,[Formula: see text]3,[Formula: see text]4,[Formula: see text]6-Penta-O-Galloyl-β-D-Glucose from Galla rhois Ameliorates Renal Tubular Injury and Microvascular Inflammation in Acute Kidney Injury Rats

The American Journal of Chinese Medicine
Ji Hun ParkHo Sub Lee

Abstract

Renal ischemia-reperfusion injury (IRI), an important cause of acute kidney injury (AKI), causes increased renal tubular injury and microvascular inflammation. 1,[Formula: see text]2,[Formula: see text]3,[Formula: see text]4,[Formula: see text]6-penta-O-galloyl-[Formula: see text]-D-glucose (PGG) from Galla rhois has anticancer, anti-oxidation and angiogenesis effects. We examined protective effects of PGG on IRI-induced acute AKI. Clamping both renal arteries for 45[Formula: see text]min induced isechemia and then reperfusion. Treatment with PGG (10[Formula: see text]mg/kg/day and 50[Formula: see text]mg/kg/day for four days) significantly ameliorated urine volume, urine osmolality, creatinine clearance (Ccr) and blood urea nitrogen (BUN). In addition, PGG increased aquaporine 1/2/3, Na[Formula: see text]-K[Formula: see text]-ATPase and urea transporter (UT-B) and decreased ICAM-1, MCP-1, and HMGB-1 expression. In this histopathologic study, PGG improved glomerular and tubular damage. Immunohistochemistry results showed that PGG increased aquaporine 1/2, and Na[Formula: see text]-K[Formula: see text] ATPase and decreased ICAM-1 expression. These findings suggest that PGG ameliorates tubular injury including tubular dysfunction...Continue Reading

References

May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·S NielsenM A Knepper
Dec 12, 2001·Kidney International·C A EcelbargerB K Kishore
Sep 17, 2003·Journal of Internal Medicine·C J TreutigerJ E W Palmblad
Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hong GongSøren Nielsen
Jul 16, 2004·Kidney International·Bruce A Molitoris, Timothy A Sutton
Mar 30, 2005·The Journal of Experimental Medicine·Allan TsungTimothy R Billiar
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
Apr 15, 2005·Journal of the American Society of Nephrology : JASN·Robert A FentonMark A Knepper
Aug 2, 2005·Nature Reviews. Drug Discovery·Luis Ulloa
Sep 27, 2005·Journal of Ethnopharmacology·Dae Gill KangHo Sub Lee
Jul 5, 2006·The Journal of Experimental Medicine·Shixin QinHuan Yang
Jul 20, 2006·American Journal of Physiology. Renal Physiology·David A SpectorJames B Wade
Jan 19, 2007·American Journal of Physiology. Renal Physiology·Christoph SchmidtMichael Bucher
Sep 4, 2009·American Journal of Physiology. Cell Physiology·Paola GalluzzoMaria Marino
Aug 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Junhua LiGang Chen
Oct 12, 2010·Kidney International·Jianlin ChenChristopher Y Lu
May 11, 2011·The Journal of Biological Chemistry·Jiang LiuJoseph I Shapiro
May 24, 2013·American Journal of Physiology. Renal Physiology·Masayuki IshiharaYoshio Terada
Dec 19, 2013·The Journal of the Royal College of Physicians of Edinburgh·S Anathhanam, A J P Lewington
Feb 11, 2014·Biochemical and Biophysical Research Communications·Wenhua ZhaoShiqi Peng
Mar 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan GaoJia-Bo Wang

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