¹H, ¹³C and ¹⁵N resonance assignments and second structure information of Gad m 1: a β-parvalbumin allergen from Atlantic cod (Gadus morhua)

Biomolecular NMR Assignments
A H MoraesAna Paula Valente

Abstract

Gad m 1 is the major allergen from Atlantic cod. It belongs to β-parvalbumin protein family and is characterized by the presence of two calcium-binding sites so called EF-hand motifs. β-Parvalbumins such as Gad m 1 are the most important fish allergens and their high cross-reactivity is the cause of the observed polysensitization to various fish species in allergic patients. Despite extensive efforts, the complete elucidation of β-parvalbumin-IgE complexes has not been achieved yet. Allergen structural studies are essential for the development of novel immunotherapy strategies, including vaccination with hypoallergenic derivatives and chimeric molecules. Here, we report for the first time the NMR study of a β-parvalbumin: Gad m 1. This report includes: (1)H, (13)C and (15)N resonance assignments of Gad m 1 as well as the second structure information based on the (13)C chemical shifts.

References

Dec 15, 2000·Current Opinion in Structural Biology·A Lewit-Bentley, S Réty
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Heimo Breiteneder, E N Clare Mills
Oct 13, 2006·Current Opinion in Immunology·Cezmi A Akdis
Jul 13, 2007·The Journal of Allergy and Clinical Immunology·Michael WallnerFatima Ferreira
Oct 16, 2007·The Journal of Allergy and Clinical Immunology·John A JenkinsE N Clare Mills
May 28, 2008·Molecular Nutrition & Food Research·Yan MaHeimo Breiteneder
Aug 11, 2010·Structure·Guilherme RazzeraAna Paula Valente

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Citations

Dec 30, 2015·Critical Reviews in Food Science and Nutrition·Telmo J R FernandesIsabel Mafra
Apr 17, 2015·Journal of Agricultural and Food Chemistry·Harmen H J de JonghStef J Koppelman

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