1H, 13C and 15N resonance assignments for the microtubule-binding domain of the kinetoplastid kinetochore protein KKT4 from Trypanosoma brucei.

Biomolecular NMR Assignments
Patryk LudziaChristina Redfield

Abstract

KKT4 is a kinetoplastid-specific microtubule-binding kinetochore protein that lacks significant similarity to any known kinetochore or microtubule-binding proteins. Here we present the 1H, 13C and 15N resonance assignments for several fragments from the microtubule-binding domain of KKT4 (KKT4115-343) from Trypanosoma brucei. These assignments provide the starting point for detailed investigations of the structure, dynamics and interactions of the microtubule-binding region of KKT4.

References

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Methods Mentioned

BETA
NMR
gel filtration

Software Mentioned

HMQC
DSS
hmsIST
BEST
TROSY
CcpNmr Analysis
SOFAST

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