1H, 15N and 13C assignments of the dimeric C-terminal domain of HIV-1 capsid protein.

Biomolecular NMR Assignments
Jinwon JungAngela M Gronenborn

Abstract

HIV-1 capsid protein (CA) encloses the viral RNA genome and forms a conical-shaped particle in the mature HIV-1 virion, with orderly capsid assembly and disassembly critically important for viral infectivity. The 231 residue CA is composed of two helical domains, connected by a short linker sequence. In solution, CA exhibits concentration dependent dimerization which is mediated by the C-terminal domain (CTD). Here, we present nearly complete (1)H, (15)N and (13)C assignments for the 20 kDa homodimeric CA-CTD, a prerequisite for structural characterization of the CA-CTD dimer.

References

Feb 21, 1998·Trends in Biotechnology·G M Clore, A M Gronenborn
Jan 5, 1999·Science·B K GanserW I Sundquist
Jul 26, 2005·Nature Structural & Molecular Biology·François TernoisFélix A Rey
Oct 10, 2007·Cell·Barbie K Ganser-PornillosMark Yeager

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Citations

Jan 23, 2010·Journal of the American Chemical Society·Yun HanTatyana Polenova
Dec 29, 2015·The Journal of Physical Chemistry. B·Rupal GuptaTatyana E Polenova
Jan 27, 2016·Antimicrobial Agents and Chemotherapy·Suzie Thenin-HoussierSusana T Valente

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