1H magnetic resonance spectroscopy at 3 T in cryptogenic and mesial temporal lobe epilepsy

NMR in Biomedicine
Franz RiedererWolfgang Serles

Abstract

The objectives of this work were to compare concentrations of N-acetylaspartate (NAA), glutamate (Glu), glutamine (Gln), Glx (=Glu + Gln), myo-inositol (mI), total creatine (Cre) and other metabolites in the temporal lobes of patients with mesial temporal lobe epilepsy (mTLE), cryptogenic TLE (cTLE), who show no abnormalities in high-resolution MRI, and healthy controls using single voxel (1)H MRS at 3 T. Twelve patients with mTLE, nine with cTLE and 22 controls were investigated using a short echo time STEAM protocol. Voxels were positioned bilaterally in the medial and lateral temporal lobes. Spectra were processed with LCModel. Significantly lower mean NAA were detected in mTLE patients (P < 0.001) and a trend towards lower NAA in cTLE patients compared to controls (P = 0.053). Glx was not different between groups. Estimates of Glu showed a different metabolic pattern in mTLE with elevated Glu in lateral compared with medial voxels on the ipsilateral side to seizure onset (P = 0.019). MI concentrations were significantly lower in cTLE (P < 0.001) and in mTLE patients (P = 0.005) compared with healthy controls. MI/Cre was significantly reduced in cTLE patients only (P = 0.004). The results confirm low NAA in mTLE and to a les...Continue Reading

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Citations

Oct 23, 2009·Epilepsia·Bruno A G CamposFernando Cendes
Jun 4, 2011·Epilepsia·Joseph O'NeillRochelle Caplan
Feb 25, 2015·Magnetic Resonance Imaging·Christopher R DurstS Sendhil Velan
Sep 10, 2014·Neuroscience·H AmhaoulS Dedeurwaerdere
Mar 17, 2021·Seizure : the Journal of the British Epilepsy Association·Estela M BruxelIscia Lopes-Cendes
Apr 15, 2021·Neuroradiology·Nadín Fernández-VegaNatalia García-Casares
Jun 10, 2008·Journal of Neuroradiology. Journal De Neuroradiologie·P Jissendi Tchofo, D Balériaux

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