1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-naive, chronic schizophrenia

Academic Radiology
B Y ChoeR E Lenkinski

Abstract

We investigated the proton metabolism of right prefrontal white matter in drug-naive, chronic schizophrenic patients (n = 23), compared with healthy normal control subjects (n = 10), by using localized, water-suppressed in vivo 1H magnetic resonance (MR) spectroscopy. All 1H MR spectroscopy examinations were performed on a 1.5-T MR imaging/MR spectroscopy system by using a point-resolved spectroscopy pulse sequence for localized volumes of 2 x 2 x 2 cm3. Proton metabolite ratios relative to creatine (Cr) were obtained using a Marquart algorithm. Drug-naive, chronic schizophrenic patients demonstrated a decrease in the N-acetylaspartate (NAA):Cr and choline (Cho):Cr ratios and an increase of the complex of gamma-aminobutyric acid (GABA) and glutamate (Glu)-containing ratio [(GABA + Glu):Cr] as compared with normal control subjects. Results suggest that the reduction of NAA and Cho may indicate neuronal dysfunction and that the elevation of GABA and Glu may play a role in chronic schizophrenia. 1H MR spectroscopy may be a useful modality in research and in the clinical evaluation of chronic schizophrenic patients.

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Citations

Aug 25, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·K OharaK Ohara
Dec 25, 2003·Schizophrenia Research·Juan BustilloC Fernando Valenzuela
Sep 22, 2001·Psychiatry Research·R F DeickenB Soher
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Jul 13, 2011·Schizophrenia Bulletin·Anouk MarsmanHilleke E Hulshoff Pol
Sep 18, 2012·Psychiatry Research·Nina Vanessa KraguljacAdrienne Carol Lahti
Mar 10, 2004·International Review of Neurobiology·Daniel G Stewart, Kenneth L Davis
Aug 3, 2004·Revista do Hospital das Clínicas·Rafael Faria SanchesAntonio Waldo Zuardi
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·P F Buckley, L Friedman
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Jun 16, 2011·Human Brain Mapping·René C W MandlHilleke E Hulshoff Pol
Nov 22, 2011·Journal of Magnetic Resonance Imaging : JMRI·John D Port, Nivedita Agarwal
Mar 28, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yusuke IwataAriel Graff-Guerrero

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