(1)H MR spectroscopy of inflammation, infection and ischemia of the brain.

European Journal of Radiology
Irina MaderUwe Klose

Abstract

Different pathologic patterns in multiple sclerosis (MS) are reflected by alterations of metabolites in (1)H MR spectroscopy of the brain. Elevated choline (Cho), lactate (Lac), lipids and macromolecules are reliable markers for acute demyelination regardless of the clinical entity (also in acute disseminated encephalomyelitis). N-acetyl-aspartate (NAA) is a suitable marker for neuronal integrity. It is reduced in acute MS lesions and in normal appearing white matter, even distant to acute and chronic-lesions. Recovery from reduced NAA levels to subnormal values during remyelination, and varying time courses of NAA in normal appearing white matter during relapsing remitting disease indicate the value of this spectroscopic marker for monitoring activity and recovery. Inositol (Ins) is increased in chronic MS lesions being a marker for astrocytic gliosis. In viral disease, Cho and Ins are always increased, whereas a reduction of NAA mostly reflects an advanced or a detoriated clinical state. In bacterial brain abscesses, numerous amino acids, lipids and Lac can be elevated. In ischemia, especially the Lac/NAA in comparison with perfusion and diffusion weighted imaging seems to be a new measure for areas of metabolic need, and may...Continue Reading

References

Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·G D GrahamJ W Prichard
Jun 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W RoserL Kappos
Jan 1, 1993·Developmental Neuroscience·A BrandD Leibfritz
Jan 1, 1994·Magnetic Resonance Imaging·M HaradaS Kannuki
Sep 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K L BeharO A Petroff
Feb 1, 1994·Brain : a Journal of Neurology·C A DavieW I McDonald
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·G D GrahamJ W Prichard
Jul 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K L Behar, T Ogino
May 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J H HwangD L Rothman
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J W PanJ N Whitaker
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Wang, S J Li
Mar 7, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·P SarchielliV Gallai
Sep 28, 1999·Current Opinion in Neurology·B D TrappR Rudick
Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S BlümlB D Ross
May 29, 2000·Brain : a Journal of Neurology·A BitschW Brück
May 24, 2001·Current Opinion in Neurology·P M Matthews, D L Arnold
May 30, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·U SeegerU Klose
Jun 1, 2002·Journal of the Neurological Sciences·Christopher C HanstockW R Wayne Martin
Oct 17, 2002·Journal of Neurology·M C TartagliaD L Arnold
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Uwe SeegerThomas Nägele
Jun 21, 2003·Stroke; a Journal of Cerebral Circulation·Jens Fiehler

❮ Previous
Next ❯

Citations

Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Natalie M ZahrAdolf Pfefferbaum
Jan 12, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Natalie M ZahrAdolf Pfefferbaum
Jul 31, 2012·International Journal of Hepatology·Rajakumar NagarajanM Albert Thomas
Sep 14, 2013·Psychopharmacology·Natalie M ZahrAdolf Pfefferbaum
Aug 27, 2014·American Journal of Veterinary Research·Inés CarreraMatthias Dennler
Dec 3, 2013·Rinshō shinkeigaku = Clinical neurology·Masafumi Harada
Aug 4, 2009·Journal of the Neurological Sciences·Mikhail F ChernovKintomo Takakura
Apr 22, 2008·European Journal of Radiology·Monika Dezortova, Milan Hajek
Apr 25, 2008·European Journal of Radiology·Milan Hajek, Monika Dezortova
Oct 28, 2014·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Fumiaki UedaToshifumi Gabata
Jun 16, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Sanz-CortésE Gratacós
Oct 2, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·C B JohnsonL D Katikaneni
Mar 31, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yohan van de LooijStéphane V Sizonenko
Mar 18, 2017·Journal of Neurosurgery. Spine·Sorin C CraciunasCarmen M Cirstea
Jul 13, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Niloufar ZarinabadAndrew C Peet
Oct 15, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guanshu LiuPeter C M van Zijl
Aug 3, 2018·Molecular Neurobiology·Jennifer L McGuireNathan K Evanson
Jan 8, 2014·Experimental and Therapeutic Medicine·Ai-Qin LinXiao-Han Zhu
Oct 28, 2014·Brain Pathology·Natalie M ZahrAdolf Pfefferbaum
Nov 1, 2015·Journal of Neonatal-perinatal Medicine·N AndescavageA du Plessis
Oct 26, 2016·Addiction Biology·Natalie M ZahrAdolf Pfefferbaum
Feb 24, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Emilio Gómez-CibeiraAna Ramos-Gonzalez
Jun 27, 2020·Pediatric Research·Barbara SchniderUNKNOWN EpoKids Research Group
Apr 24, 2017·Neurochemical Research·Annamaria VezzaniTeresa Ravizza
Mar 16, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sina EhsaniAlireza Montazerabadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Disseminated Encephalomyelitis

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system. Discover the latest research on acute disseminated encephalomyelitis here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Abscess

Brain abscess is an accumulation of pus caused by inflammation and infected materials in the brain. Symptoms include fever, headache, seizures and other neurological problems. Discover the latest research on brain abscess today.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.