PMID: 7547183Feb 1, 1995Paper

1H MR visible lipids in colon tissue from normal and carcinogen-treated rats

NMR in Biomedicine
K M BrièreI C Smith

Abstract

Metabolic characteristics of colon mucosa, submucosa, muscularis and tumour specimens from four control (n = 105) and nine carcinogen (azoxymethane)-treated (n = 91) Sprague-Dawley rats were investigated by ex vivo 1H MRS. Ninety-seven per cent of pure mucosa samples (n = 59) yielded spectra with narrow lipid resonances (chemical shift delta of -(CH2)n-, 1.3 ppm; linewidth at half-height v1/2, 30-50 Hz). Eighty-two per cent of control mucosa samples with histologically proven submucosa contamination (n = 11) and 46% of control cross-sections (containing mucosa, submucosa and muscularis; n = 57) yielded spectra with broad lipid resonances (delta-(CH2)n-, 1.5 ppm; v1/2, 80-100 Hz) identical to those of adipose tissue surrounding rat colon. Thirty per cent of tumour samples (n = 10) yielded spectra with narrow lipid resonances while 70% contained no significant amount of MR visible lipids. We conclude that (i) lipids giving rise to broad resonances are in the heterogeneously distributed adipocytes of submucosa, (ii) lipids giving rise to narrow resonances are within the mucosa in an unknown structural environment, and (iii) the type and distribution of lipids in human and rat colon are similar. Tumours contained significantly more...Continue Reading

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Citations

Jun 1, 1996·NMR in Biomedicine·D EndeC E Mountford
May 19, 2010·Biomarkers in Medicine·G A Nagana GowdaTedros Bezabeh
May 4, 2011·NMR in Biomedicine·E James DelikatnyHarish Poptani
Feb 3, 2007·Journal of Proteome Research·Julian L Griffin, Risto A Kauppinen

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