1H-MRS at 4 tesla in minimally treated early schizophrenia.

Molecular Psychiatry
Juan R BustilloJohn Lauriello

Abstract

We investigated glutamate-related neuronal dysfunction in the anterior cingulate (AC) early in schizophrenia before and after antipsychotic treatment. A total of 14 minimally treated schizophrenia patients and 10 healthy subjects were studied with single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) of the AC, frontal white matter and thalamus at 4 T. Concentrations of N-acetylaspartate (NAA), glutamate (Glu), glutamine (Gln) and Gln/Glu ratios were determined and corrected for the partial tissue volume. Patients were treated with antipsychotic medication following a specific algorithm and (1)H-MRS was repeated after 1, 6 and 12 months. There were group x region interactions for baseline NAA (P=0.074) and Gln/Glu (P=0.028): schizophrenia subjects had lower NAA (P=0.045) and higher Gln/Glu (P=0.006) in the AC before treatment. In addition, AC Gln/Glu was inversely related to AC NAA in the schizophrenia (P=0.0009) but not in the control group (P=0.92). Following antipsychotic treatment, there were no further changes in NAA, Gln/Glu or any of the other metabolites in any of the regions studied. We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reducti...Continue Reading

References

May 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·T R Barnes
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Dec 1, 1995·Archives of General Psychiatry·J W Olney, N B Farber
Jun 1, 1997·The American Journal of Psychiatry·R J BaldessariniF M Benes
Apr 29, 1998·Archives of General Psychiatry·K O LimA Pfefferbaum
Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W M BrooksC A Stidley
Feb 25, 1999·Journal of Magnetic Resonance Imaging : JMRI·H PetropoulosW M Brooks
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P J Magistretti, L Pellerin
Oct 9, 1999·Psychiatry Research·A PfefferbaumK O Lim
Jan 13, 2000·Archives of General Psychiatry·L A Glantz, D A Lewis
Mar 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D M LindquistR A Komoroski
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R BarthaP C Williamson
Dec 6, 2001·Hippocampus·J W Newcomer, J H Krystal
Dec 25, 2003·Schizophrenia Research·Juan BustilloC Fernando Valenzuela
Jan 29, 2005·The American Journal of Psychiatry·Laura M RowlandWilliam M Brooks
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R Grant SteenJeffrey A Lieberman
Sep 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juan BustilloMatthew P Galloway
Mar 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xavier López-GilAlbert Adell
Oct 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Jean ThébergePeter C Williamson
Dec 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juan R BustilloJohn Lauriello

❮ Previous
Next ❯

Citations

Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camilo de la Fuente-SandovalAriel Graff-Guerrero
Jul 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alice EgertonJames M Stone
Jul 19, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina V KraguljacAdrienne C Lahti
Jul 13, 2011·Schizophrenia Bulletin·Anouk MarsmanHilleke E Hulshoff Pol
Sep 15, 2011·Schizophrenia Bulletin·Frank JessenFrank Träber
Oct 20, 2012·Schizophrenia Bulletin·Laura M RowlandPeter B Barker
Oct 1, 2011·Science Translational Medicine·Daniel C JavittChi-Ming Lee
May 9, 2014·Neurotoxicity Research·Trevor ArcherMax Rapp Ricciardi
Sep 4, 2015·Schizophrenia Bulletin·Jürgen GallinatMartin Schaefer
Sep 18, 2012·Psychiatry Research·Nina Vanessa KraguljacAdrienne Carol Lahti
Aug 7, 2012·Schizophrenia Research·D Y LeeD J Lang
Sep 14, 2015·The International Journal of Neuropsychopharmacology·Camilo de la Fuente-SandovalDikoma C Shungu
Mar 31, 2015·Biochemical and Biophysical Research Communications·Tianbin SongKefeng Li
Apr 22, 2015·The International Journal of Neuropsychopharmacology·Anna HöflichRupert Lanzenberger
Jan 22, 2015·The International Journal of Neuropsychopharmacology·Meghan Elizabeth GoldsteinBruce R Russell
Jan 15, 2014·Schizophrenia Research·Eline M P PoelsRagy R Girgis
Sep 17, 2013·Neuroscience and Biobehavioral Reviews·Gagan FervahaGary Remington
Jul 23, 2014·Molecular Psychiatry·R S Kahn, I E Sommer
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·S Andrea WijtenburgLaura M Rowland
Sep 8, 2010·Behavioural Brain Research·Corinna Haenschel, David Linden
Jan 15, 2015·Journal of Psychopharmacology·Oliver HowesJames Stone
Sep 1, 2016·Brain Structure & Function·Anna HöflichRupert Lanzenberger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here