¹H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet

PloS One
Ze-Yun LiZheng-Tao Wang

Abstract

Curcumin, a principle bioactive component of Curcuma longa L, is well known for its anti-hyperlipidemia effect. However, no holistic metabolic information of curcumin on hyperlipidemia models has been revealed, which may provide us an insight into the underlying mechanism. In the present work, NMR and MS based metabolomics was conducted to investigate the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet (HFD) feeding for 12 weeks. The HFD induced animals were orally administered with curcumin (40, 80 mg/kg) or lovastatin (30 mg/kg, positive control) once a day during the inducing period. Serum biochemistry assay of TC, TG, LDL-c, and HDL-c was conducted and proved that treatment of curcumin or lovastatin can significantly improve the lipid profiles. Subsequently, metabolomics analysis was carried out for urine samples. Orthogonal Partial Least Squares-Discriminant analysis (OPLS-DA) was employed to investigate the anti-hyperlipidemia effect of curcumin and to detect related potential biomarkers. Totally, 35 biomarkers were identified, including 31 by NMR and nine by MS (five by both). It turned out that curcumin treatment can partially recover the metabolism disorders induced by HFD, with the foll...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Investigation·S JacksonD M Turnbull
Mar 5, 1991·Biochemistry·K Y Tserng, S J Jin
Sep 18, 1990·Biochemistry·S J Jin, K Y Tserng
Mar 1, 1989·The Medical Clinics of North America·W H Frishman, R C Rapier
Jan 1, 1986·Annual Review of Nutrition·C J Rebouche, D J Paulson
Sep 16, 1974·European Journal of Biochemistry·S M Bernson, D G Nicholls
Jul 17, 1999·Atherosclerosis·O Stein, Y Stein
Sep 16, 1999·Atherosclerosis·N JacobG Turpin
Aug 5, 2000·Primary Care·J N YuD Liu
Jul 18, 2002·Nature Reviews. Drug Discovery·Jeremy K NicholsonElaine Holmes
Jul 24, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Keow G SimBridget Wilcken
Oct 25, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R E WilliamsW M Provan
May 30, 2003·American Journal of Physiology. Endocrinology and Metabolism·H PiloquetM Krempf
Jan 20, 2005·Journal of Agricultural and Food Chemistry·Yulan WangElaine Holmes
Apr 12, 2005·Nature Reviews. Microbiology·Jeremy K NicholsonIan D Wilson
May 23, 2006·The Journal of Nutritional Biochemistry·Dieter PeschelNorbert Nass
Sep 7, 2006·Analytical and Bioanalytical Chemistry·Zhengzheng Pan, Daniel Raftery
Sep 28, 2006·Clinical and Experimental Pharmacology & Physiology·Sameer SharmaKanwaljit Chopra
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·H Manjunatha, K Srinivasan
Jan 25, 2008·Diabetes, Obesity & Metabolism·J ShearerH J Vogel
Apr 9, 2008·Journal of Clinical Biochemistry and Nutrition·Sutapa MukherjeeRathindra K Bhattacharya
May 13, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jinchun SunRichard D Beger
Oct 23, 2008·Metabolism: Clinical and Experimental·Eun-Mi JangMi-Kyung Lee
Dec 23, 2009·Medicinal Research Reviews·Dinesh Kumar Agrawal, Pushpesh Kumar Mishra
Oct 26, 2010·Methods in Molecular Biology·Frank DieterleAlexander Amberg
Dec 21, 2010·Analytica Chimica Acta·D RyanMegan Kendall
Mar 26, 2011·Trends in Biotechnology·Hye Kyong KimRobert Verpoorte
Dec 14, 2011·Journal of Pharmaceutical and Biomedical Analysis·Tie ZhaoPing Li
Jun 12, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dora Il'yasovaIvan Spasojevic
Sep 14, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Aihua ZhangXijun Wang
Jan 23, 2013·BioFactors·Jean-Marc ZinggMohsen Meydani
Feb 7, 2013·Frontiers of Medicine·Jingyi LuWei Jia
Mar 19, 2013·Journal of Pharmaceutical and Biomedical Analysis·Xingfang SongLingyi Kong

❮ Previous
Next ❯

Citations

Oct 23, 2015·International Journal of Molecular Sciences·Léa GauthierFlorence Richard-Forget
Feb 24, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shao LiuHai-Tao Liu
Oct 2, 2015·Current Opinion in Biotechnology·Sooah KimKyoung Heon Kim
Dec 15, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jian ShiChang-Xiao Liu
Jul 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Sha DiXiaolin Tong
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdul-Hamid EmwasMariusz Jaremko
Nov 19, 2020·Nutrients·Noor Atiqah Aizan Abdul KadirIntan Safinar Ismail
Jan 21, 2017·Analytical Chemistry·G A Nagana Gowda, Daniel Raftery

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
NMR
PCA

Software Mentioned

SPSS
TOPSPIN
AMIX
Chenomx
DA
OPLS
SIMCA
Micromass MarkerLynx Application Manager

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.