¹H-NMR-Based Metabonomics of the Protective Effect of Coptis chinensis and Berberine on Cinnabar-Induced Hepatotoxicity and Nephrotoxicity in Rats

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Guangyue SuJiao Bai

Abstract

Coptis chinensis Franch has been used in Traditional Chinese Medicine (TCM) for treating infectious and inflammatory diseases for over two thousand years. Berberine (BN), an isoquinoline alkaloid, is the main component of Coptis chinensis. The pharmacological basis for its therapeutic effects, which include hepatoprotective effects on liver injuries, has been studied intensively, yet the therapy of liver injuries and underlying mechanism remain unclear. We investigated the detoxification mechanism of Coptis chinensis and berberine using metabolomics of urine and serum in the present study. After the treatment with Coptis chinensis and berberine, compared with the cinnabar group, Coptis chinensis and berberine can regulate the concentration of the endogenous metabolites. PLS-DA score plots demonstrated that the urine and serum metabolic profiles in rats of the Coptis chinensis and berberine groups were similar those of the control group, yet remarkably apart from the cinnabar group. The mechanism may be related to the endogenous metabolites including energy metabolism, amino acid metabolism and metabolism of intestinal flora in rats. Meanwhile, liver and kidney histopathology examinations and serum clinical chemistry analysis ve...Continue Reading

References

Mar 9, 2004·Drug Discovery Today·Royston Goodacre
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Bombi LeeInsop Shim
Jul 27, 2010·Analytical Biochemistry·Linsheng LiuZimei Wu
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qian ZhangSung Woo Kim
Oct 25, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kahkashan RashidParames C Sil
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mohamed S OthmanAhmed E Abdel Moneim
Jan 5, 2016·Molecular Cell·Inmaculada Martínez-ReyesNavdeep S Chandel
Oct 19, 2016·Biotechnology Advances·Daotong LiFang Chen
Oct 19, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaopeng ZhuXin Gao
Oct 30, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hussain Mohamad AwwadRima Obeid
Feb 19, 2017·Biochimica Et Biophysica Acta. Bioenergetics·Luisa IommariniAnna Maria Porcelli
Feb 28, 2017·Tissue & Cell·Nawal Al-MukhainiKawthar Al-Adawi
Apr 23, 2017·The Journal of Nutritional Biochemistry·Pablo Hernández-AlonsoMònica Bulló
Jul 14, 2017·Journal of the Mechanical Behavior of Biomedical Materials·Baukje HemmesMartijn Poeze
Jul 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian LiangJinbin Yuan
Jul 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan-Xiang WangDan-Qing Song

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Citations

Apr 7, 2021·The Journal of Pharmacy and Pharmacology·Janiqua RolleRaphael N Alolga
Oct 18, 2020·European Journal of Pharmacology·Mengting ZhouYunxia Li

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Methods Mentioned

BETA
NMR
light microscopy

Software Mentioned

SIMCA
SPSS
MestReNova

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