1H NMR investigations of the molecular nature of cobalt(II) ions in human saliva

Archives of Biochemistry and Biophysics
Hubert ChangMartin Grootveld

Abstract

High-resolution (1)H NMR spectroscopy demonstrated that addition of Co(II) ions to isolated human salivary supernatants (HSSs) gave rise to its complexation by a variety of biomolecules. The relative efficacies of these complexants/chelators in this context were classifiable by the influence of added Co(II) on their line-widths and chemical shift values, and also the added Co(II) concentration-dependence of these spectral modifications. Those which were most affected by the addition of this metal ion were lactate > formate ≈histidinate > succinate, this order reflecting the ability of these complexants to compete for the available Co(II) in terms of (1) thermodynamic equilibrium constants for the formation of their complexes and (2) their HSS concentrations. Since many of these HSS Co(II) complexants (particularly lactate, formate and histidine) serve as powerful ()OH scavengers, the results acquired indicate that any of this radical generated from the Co(II) source in such complexes via pseudo-Fenton reactions may be 'site-specifically' scavenged. The significance of these observations regarding the in vivo corrosion of cobalt-containing metal alloy dental prostheses (e.g., Co-Cr alloys), the availability of trace levels of th...Continue Reading

References

Nov 15, 1989·Archives of Biochemistry and Biophysics·M B KadiiskaR P Mason
Sep 1, 1988·Journal of Oral Rehabilitation·P R MezgerE H Greener
Aug 1, 1988·FEBS Letters·J D BellP J Sadler
May 1, 1985·Biomaterials·H J Mueller
Jan 1, 1983·Acta Odontologica Scandinavica·J F de MeloE S Erichsen
Aug 1, 1982·Journal of Clinical Microbiology·G O GuerrantC W Moss
May 1, 1994·The Journal of Bone and Joint Surgery. American Volume·S S UpadhyayA C Yau
Aug 28, 1998·Journal of Inorganic Biochemistry·S LeonardX Shi
Jan 13, 2000·Toxicology and Applied Pharmacology·G RoesemsB Nemery
Apr 15, 2000·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·V HerynekR A Brooks
Feb 24, 2001·The Journal of Prosthetic Dentistry·S P Humphrey, R T Williamson
Aug 4, 2001·Toxicology and Applied Pharmacology·J S Fedan, D Cutler
Feb 28, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Christopher L SilwoodEdward Lynch
Apr 30, 2002·Free Radical Biology & Medicine·Shosuke KawanishiShinji Oikawa
May 9, 2002·Journal of Toxicology and Environmental Health. Part a·Alexander PilgerWolf Osterode
Jul 5, 2002·Journal of Dental Research·C J L SilwoodM C Grootveld
Feb 1, 1952·Journal of Dental Research·S DREIZENT D SPIES
Feb 11, 2005·Biomaterials·Lucien ReclaruChristian Susz
Feb 22, 2005·Biochemical and Biophysical Research Communications·Martin Grootveld, Christopher J L Silwood
Jan 16, 2007·Journal of Oral Science·Yoshiaki NomuraKyuichi Kamoi
Jan 17, 2008·Journal of Materials Science. Materials in Medicine·Mohit SharmaNirbhay Singh
Feb 1, 2011·Antioxidants & Redox Signaling·Ute JungwirthPetra Heffeter

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