1H NMR measurements of wet/dry ratio and T1, T2 distributions in lung

Journal of Magnetic Resonance
M EstilaeiJ R Mayo

Abstract

Proton-magnetic-resonance measurements have been carried out on juvenile porcine peripheral lung parenchyma. The free-induction-decay signal contained a motionally restricted component which decayed in a few tens of microseconds and a mobile component with a T2 time greater than 1 ms. The average second moment, M2, for the motionally restricted signal was found to be 3.42 +/- (0.25) x 10(9) s-2. The T2 distribution for the mobile signal consistently showed four resolvable components of T2 range: 2-6, 10-40, 80-110, and 190-400 ms. The 2-6 ms component was present in a fully dehydrated preparation and was therefore assigned to a nonaqueous lung constituent. The motionally restricted FID component had a T1 = 0.772 +/- 0.11 s and the mobile component had a T1 = 0.967 +/- 0.02 s. The hydrogen content per unit mass for lung parenchyma and water were estimated in two ways: (1) on the basis of chemical content and (2) on the basis of comparison of restricted and mobile signals to the gravimetric (G) water content for a lung sample studied at a wide range of water contents. Lung wet/dry weight ratios were estimated from the free-induction decays and compared with gravimetric measurement. The ratio of (wet/dry)NMR/(wet/dry)G was 1.00 +/...Continue Reading

References

Jul 1, 1986·Journal of Thoracic Imaging·A G CutilloT A Case
Aug 1, 1986·Thorax·B C Starcher
Nov 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Stegemann, K Stalder
Jun 18, 1982·Science·C E HayesS A Johnson
Feb 1, 1996·Journal of Magnetic Resonance. Series B·A HackmannA G Cutillo

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Citations

Feb 9, 2017·Pediatric Research·Ali HoueijehLaurent Storme
Jun 18, 1999·Journal of Magnetic Resonance Imaging : JMRI·K W StockR R Edelman
Jun 27, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Logi VidarssonChristopher K Macgowan
May 20, 1999·Journal of Magnetic Resonance Imaging : JMRI·M EstilaeiJ Mayo
Apr 26, 2001·NMR in Biomedicine·F R FenrichP S Allen

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