1p/19q codeletion and IDH1/2 mutation identified a subtype of anaplastic oligoastrocytomas with prognosis as favorable as anaplastic oligodendrogliomas

Neuro-oncology
Haihui JiangSong Lin

Abstract

Anaplastic astrocytoma (AA), anaplastic oligoastrocytoma (AOA), and anaplastic oligodendroglioma (AO) are the major histological subtypes of World Health Organization grade III gliomas. More evidence suggests that AOA is unlikely to be a distinct entity, and re-evaluation of this issue has been recommended. In this study, we divided AOA into 2 subgroups, according to molecular biomarkers, and compared the survivals between them. One hundred nine patients with histological diagnosis of anaplastic gliomas enrolled in the study. Molecular biomarkers evaluated included 1p/19q codeletion and IDH1/2 mutation. Kaplan-Meier plots were compared by log-rank method. There was no significant difference between AA and AOA with regard to the frequencies of biomarkers and survival plots. According to the status of biomarkers, AOA was classified into 2 subgroups (AOA1 and AOA2), for which Kaplan-Meier plots were significantly different (P = .001 for both progression-free survival [PFS] and overall survival [OS]). AOA1 with 1p/19q codeletion and/or IDH1/2 mutation showed similar Kaplan-Meier plots with AO (P = .169 for PFS and P = .523 for OS). AOA2 without either biomarker showed similar Kaplan-Meier plots with AA (P = .369 for PFS and P = .27...Continue Reading

References

Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S SmithR B Jenkins
Dec 18, 2001·Medical and Pediatric Oncology·P F AmbrosUNKNOWN SIOP Europe Neuroblastoma Pathology, Biology, and Bone Marrow Group
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Intergroup Radiation Therapy Oncology Group Trial 9402Walter Curran
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Ryan MillerArie Perry
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Feb 28, 2009·The American Journal of Pathology·Takuya WatanabeHiroko Ohgaki
Nov 16, 2010·The American Journal of Pathology·Young-Ho KimHiroko Ohgaki

❮ Previous
Next ❯

Citations

Aug 25, 2016·Oncotarget·Yan-Xi LiHo-Keung Ng
Feb 28, 2015·Surgical Neurology International·Emilie Le RhunMarc C Chamberlain
Aug 26, 2014·Journal of Neuro-oncology·Haihui JiangSong Lin
May 7, 2015·Acta Neuropathologica·Pieter WesselingArie Perry
Feb 19, 2016·Scientific Reports·Dapeng WangArnold B Etame
May 7, 2015·Neuropathology and Applied Neurobiology·Sebastian Brandner, Andreas von Deimling
Oct 29, 2013·Journal of Neuro-oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Sep 30, 2017·Journal of Pathology and Translational Medicine·Seong-Ik KimSung-Hye Park
Aug 23, 2019·Human Pathology·Marion BeaumontUNKNOWN CARARE French network (Rare Renal Carcinoma in Adults) of the INCa (National Institute of Cancer, France)
Jul 17, 2021·Brain Tumor Pathology·Masahiro MizoguchiToru Iwaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.