β2 -Adrenergic Receptor Activation Suppresses the Rat Phenethylamine Hallucinogen-Induced Head Twitch Response: Hallucinogen-Induced Excitatory Post-synaptic Potentials as a Potential Substrate

Frontiers in Pharmacology
Gerard J Marek, Brian P Ramos

Abstract

5-Hydroxytryptamine2A (5-HT2A) receptors are enriched in layers I and Va of the rat prefrontal cortex and neocortex and their activation increases the frequency of glutamatergic excitatory post-synaptic potentials/currents (EPSP/Cs) onto layer V pyramidal cells. A number of other G-protein coupled receptors (GPCRs) are also enriched in cortical layers I and Va and either induce (α1-adrenergic and orexin2) or suppress (metabotropic glutamate2 [mGlu2], adenosine A1, μ-opioid) both 5-HT-induced EPSCs and head twitches or head shakes induced by the phenethylamine hallucinogen 2,5-dimethoxy-4-iodoamphetamine (DOI). Another neurotransmitter receptor also localized to apparent thalamocortical afferents to layers I and Va of the rat prefrontal cortex and neocortex is the β2-adrenergic receptor. Therefore, we conducted preliminary electrophysiological experiments with rat brain slices examining the effects of epinephrine on electrically-evoked EPSPs following bath application of DOI (3 μM). Epinephrine (0.3-10 μM) suppressed the late EPSPs produced by electrical stimulation and DOI. The selective β2-adrenergic receptor antagonist ICI-118,551 (300 nM) resulted in a rightward shift of the epinephrine concentration-response relationship. W...Continue Reading

References

Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T C RainbowB B Wolfe
Apr 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·Y LecrubierD Widlocher
Feb 1, 1995·Journal of Clinical Psychopharmacology·J A BodkinJ O Cole
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J C Gewirtz, G J Marek
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·Aleksandra KłodzinskaAndrzej Pilc
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gerard J MarekLawrence H Price
Aug 12, 2003·European Journal of Pharmacology·Gerard J Marek
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Aug 1, 1963·The American Journal of Psychiatry·E T CARLSON, M M SIMPSON
Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Evelyn K Lambe, George K Aghajanian
Feb 17, 2007·Pharmacology & Therapeutics·Brian P Ramos, Amy F T Arnsten
Mar 17, 2007·Neurobiology of Aging·Brian P RamosAmy F T Arnsten
Feb 26, 2008·Nature·Javier González-MaesoStuart C Sealfon
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Dec 3, 2016·Current Topics in Behavioral Neurosciences·Michael Kometer, Franz X Vollenweider
Sep 25, 2017·Acta Psychiatrica Scandinavica·F MüllerS Borgwardt

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