2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia

The Journal of Pharmacology and Experimental Therapeutics
Yi ZhangXiaoliang Wang

Abstract

2-(1-Hydroxypentyl)-benzoate (dl-PHPB), a derivate of 3-n-butylphthalide (dl-NBP), is a novel drug candidate used for treatment of cerebral ischemia. The goal of the present study was to investigate the effects of dl-PHPB on infarct volume, neurological function, and cerebral blood flow (CBF) in transient focal cerebral ischemia. Therefore, an animal model of 2-h middle cerebral artery occlusion (MCAO) followed by 24-h reperfusion was used. Rats received dl-PHPB (1.3, 3.9, or 12.9 mg/kg) intravenously 10 min after the onset of MCAO. Compared with the vehicle control group (37.4%), infarct volume in dl-PHPB-treated groups was reduced significantly and dose-dependently to 25.4, 17.4, and 13.7%, respectively. The changes in neurological deficient were also observed in neurobehavioral test in a dose-dependent manner, and the neuronal score was improved significantly from the vehicle control of 3.2 to 2.7, 2.1, and 1.8, respectively. At the highest dose, the potency of dl-PHPB was similar to those of dl-NBP. CBF was quantified by using laser-Doppler flowmetry. During the ischemia, the regional CBF values of dl-PHPB groups were significantly higher than that of vehicle group. In addition, our study showed that dl-PHPB converted into ...Continue Reading

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Citations

Jul 26, 2012·Journal of Medicinal Chemistry·Jing WuYihua Zhang
Sep 27, 2008·Acta Pharmacologica Sinica·Rong HanZheng-hong Qin
May 10, 2011·Neurosurgery·Yi ZhangRobert M Friedlander
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Mar 20, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Hongyan YangXiaoliang Wang
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Nov 3, 2017·Medicinal Research Reviews·Catarina OliveiraFernanda Borges
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Oct 18, 2020·International Journal of Molecular Sciences·Xinyue DongZhenjia Wang

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