2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis

Fitoterapia
Ge LiaoHao-Fu Dai

Abstract

Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated by spectroscopic (NMR, UV, IR, MS) methods, Mosher's method, and comparison with reported data in the literatures. Among those, compounds 8, 12, and 14 exhibited significant inhibition against α-glucosidase in vitro with IC50 values of 0.15, 0.05, and 0.09mM, respectively (with acarbose as the positive control; IC50: 0.98mM). In addition, compounds 3, 9, 11, and 14 showed weak inhibitory activity against AChE; and compounds 12 and 13 displayed weak cytotoxicity against human gastric cell line (SGC-7901) among three types of tested human cancer cell lines (BEL-7402, K562, and SGC-7901).

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Citations

Aug 10, 2016·Fitoterapia·Hong-Ni WangHao-Fu Dai
Feb 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuai WangJianhe Wei
May 7, 2019·Journal of Asian Natural Products Research·Chun-Ge LiZheng-Tao Wang
Oct 7, 2017·Journal of Asian Natural Products Research·Hong-Ni WangHao-Fu Dai
May 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ge LiaoHao-Fu Dai
Dec 19, 2020·Journal of Asian Natural Products Research·Pan XiangHao-Fu Dai
Oct 31, 2017·Journal of Natural Products·Chi Thanh MaJeong Hill Park
Dec 28, 2021·Journal of Asian Natural Products Research·Jun-Tao LiHao-Fu Dai

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