PMID: 3005958Jan 1, 1986Paper

2-(4-phenylpiperidino) cyclohexanol (AH5183) decreases quantal size at the frog neuromuscular junction

Pflügers Archiv : European journal of physiology
W Van der Kloot


AH5183 was studied because it inhibits acetylcholine transport into synaptic vesicles. The drug apparently is a slow-acting anti-cholinesterase, so further experiments were performed with this enzyme inhibited. Soaking for hours in AH5183 in Ringer does not decrease quantal size. However, a few minutes of tetanic nerve stimulation results in a marked decrease in quantal size. Quantal size also decreased after hours in a hypertonic Ringer containing the drug.


Jul 1, 1975·British Journal of Pharmacology·I G Marshall, R L Parsons
Jul 1, 1975·British Journal of Pharmacology·I G Marshall, R L Parsons
Jan 15, 1985·Experientia·W Van der Kloot, T E Van der Kloot
May 1, 1970·British Journal of Pharmacology·I G Marshall
Jan 1, 1982·Journal of Neuroscience Research·G E de MottaJ del Castillo
Jun 28, 1954·The Journal of Physiology·J DEL CASTILLO, B KATZ
Jul 11, 1957·The Journal of Physiology·B KATZ, S THESLEFF

❮ Previous
Next ❯


Jul 9, 1991·European Journal of Pharmacology·P AasF Fonnum
Jan 1, 1991·Progress in Neurobiology·W Van der Kloot
Jul 29, 2009·Molecular and Cellular Biology·Braulio M de CastroVania F Prado
Feb 16, 2000·The Journal of Physiology·W Van der KlootJ Molgó
Jan 1, 1987·Annals of the New York Academy of Sciences·S M ParsonsG A Rogers
Jul 1, 1996·Pflügers Archiv : European journal of physiology·E Brailoiu, W V der Kloot
Apr 1, 1988·British Journal of Pharmacology·D EstrellaI G Marshall

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.