PMID: 6408259Jul 1, 1983

2-(6-carboxyhexyl)cyclopentanone hexylhydrazone. A potent and time-dependent inhibitor of platelet aggregation

Journal of Medicinal Chemistry
N I GhaliG C Le Breton

Abstract

Two new azaprostanoids, a hydrazone (3) and hydrazide (4), have been prepared by the condensation of 2-(6-carboxyhexyl)cyclopentanone with n-hexylhydrazine and caproic acid hydrazide. Preliminary results with the stable hydrazide 4 indicate that it inhibits arachidonic acid (AA) induced human platelet aggregation and that, unlike 13-azaprostanoic acid (1), its site of action is at the cyclooxygenase level. Results with the unstable hydrazone derivative 3 indicate it to be a potent and time-dependent inhibitor of AA-induced human platelet aggregation, with its site of action also at the cyclooxygenase level.

Related Concepts

2-(6-carboxyhexyl)cyclopentanone hexylhydrazone
Eicosatetraenoic Acids
Saturated Fat
In Vivo NMR Spectroscopy
Platelet Aggregation
Prostanoic Acids
Mass Spectrometry
Arachidonic Acid, Zinc Salt, (all-Z)-Isomer

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