2-Acetylthienopyridine Synthesis via Thiolation and Copper-Catalyzed Cyclization of o-Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate

The Journal of Organic Chemistry
Yibiao LiLu Chen

Abstract

2-Acylthienopyridines and related heterocycles are readily prepared in moderate to good yields under mild conditions by a nucleophilic thiolation, copper-catalyzed cyclization, and an oxidation cascade process using potassium xanthate as the thiol source. Moreover, excellent chemoselectivity, broad substrate scope, and good functional group tolerance are prominent features of this transformation.

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Citations

Feb 3, 2021·Organic & Biomolecular Chemistry·Nallappan SundaraveluGovindasamy Sekar
Feb 11, 2021·Organic & Biomolecular Chemistry·Yuan ZhangHongwei Zhou
Dec 4, 2019·Organic Letters·Peiqi ZhouHuanfeng Jiang

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