β2-Adrenergic receptor desensitization in perirenal adipose tissue in fetuses and lambs with placental insufficiency-induced intrauterine growth restriction.

The Journal of Physiology
Xiaochuan ChenS W Limesand

Abstract

Placental insufficiency-induced intrauterine growth restriction (IUGR) fetuses have chronic hypoxaemia and elevated plasma catecholamine concentrations. In this study, we determined whether adrenergic responsiveness becomes desensitized in the perirenal adipose tissue of IUGR fetuses and lambs by measuring adrenergic receptor (AR) mRNA and protein levels. We also tested the ability of adrenaline to mobilize non-esterified fatty acids (NEFAs) in young lambs. Perirenal adipose tissue was collected from IUGR and control fetuses at 133 days of gestational age (dGA) and lambs at 18 days of age (dA). β(2)-AR mRNA concentrations were 59% and 74% lower (P < 0.05) in IUGR fetuses and lambs compared to controls, respectively, which also resulted in lower protein levels (P < 0.05). No treatment differences were detected for α(1A)-, α(1B)-, α(1D)-, α(2A)-, α(2B)-, α(2C)-, β(1)- and β(3)-AR expression. mRNA concentrations were also determined for hormone sensitive lipase (HSL), perilipin (lipid droplet-associated protein), and two adipokines, leptin and adiponectin. Adiponectin and HSL were not different between treatments at either age. Compared to controls, perilipin and leptin mRNA concentrations were lower (P < 0.05) in IUGR fetuses but...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Sep 1, 1992·The American Journal of Physiology·P J ThureenR B Wilkening
Jan 1, 1991·Annual Review of Biochemistry·H G DohlmanR J Lefkowitz
Jan 1, 1991·Annual Review of Physiology·S CollinsR J Lefkowitz
Jan 1, 1990·Gynecologic and Obstetric Investigation·M SantalaM Parviainen
Oct 1, 1987·The Journal of Clinical Investigation·J PadburyJ Humme
Aug 1, 1995·Pediatric Research·A C Hokken-KoelegaS L Drop
Mar 1, 1994·The Journal of Clinical Investigation·I García-Higuera, F Mayor
Jun 25, 1998·The American Journal of Physiology·J M Bassett, C Hanson
Aug 5, 1998·The American Journal of Physiology·J M Bassett, M E Symonds
May 18, 1999·American Journal of Obstetrics and Gynecology·H L GalanF C Battaglia
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L H BaumgardD E Bauman
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M Bassett, C Hanson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 6, 2003·The Journal of Endocrinology·M E SymondsT Stephenson
Aug 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Barbra de VrijerFrederick C Battaglia
Nov 17, 2004·IUBMB Life·John T TanseyConstantine Londos
Sep 27, 2005·Cellular Signalling·González-Yanes Carmen, Sánchez-Margalet Víctor
May 17, 2006·Trends in Ecology & Evolution·Peter D GluckmanHamish G Spencer
Jun 20, 2006·Physiology & Behavior·D S Fernandez-Twinn, S E Ozanne
Mar 17, 2007·Heart Failure Reviews·V Melih AltanA Tanju Ozcelikay
Sep 27, 2007·American Journal of Physiology. Endocrinology and Metabolism·Sean W LimesandWilliam W Hay
Jun 11, 2008·The American Journal of Clinical Nutrition·Hilkka YlihärsiläJohan G Eriksson
Feb 17, 2009·The Journal of Physiology·Gordon B Drummond
Jan 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Rafael A LeosSean W Limesand
Mar 13, 2010·The Journal of Endocrinology·Alice S GreenSean W Limesand

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Citations

Jun 15, 2014·Journal of Molecular Endocrinology·Jacqueline M WallaceClare L Adam
Oct 10, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jay S JohnsonLance H Baumgard
Sep 6, 2014·Frontiers in Chemistry·Susan K DuckettScott L Pratt
Nov 27, 2016·The Journal of Endocrinology·Xiaochuan ChenSean W Limesand
Mar 8, 2016·Journal of Dairy Science·A P A MonteiroS Tao
Jan 9, 2015·Journal of Animal Science·J S JohnsonL H Baumgard
Jan 9, 2015·Journal of Animal Science·J S JohnsonL H Baumgard
May 12, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leticia E CamachoSean W Limesand
Aug 16, 2016·Journal of Dairy Science·A P A MonteiroG E Dahl
Feb 13, 2019·Journal of Animal Science·Sha TaoThiago N Marins
Nov 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Xiaochuan ChenSean W Limesand
Feb 27, 2020·American Journal of Physiology. Endocrinology and Metabolism·Ana-Mishel SpiroskiFrank Harry Bloomfield
Jul 16, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa A DavisSean W Limesand
Apr 8, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dustin T YatesSean W Limesand

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