β₂-adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: antagonism by vitamin D₃ and curcumin

European Journal of Pharmacology
Serene XavierChiramadathikudiyil Skaria Paulose

Abstract

Diabetes mellitus is a heterogeneous disease and nutritional therapy forms a necessary dimension for its long-term management. Traditional medicinal plants and vitamins are the potentially useful natural products for diabetes control. Diabetes causes atrophy and wasting of skeletal muscles resulting in major peripheral damage. The current study was designed to investigate the therapeutic effect of vitamin D₃ and curcumin treatment on β₂-adrenoceptors, transcription factor CREB, insulin receptors, protein kinase B (Akt) and malate dehydrogenase activity in the skeletal muscle of diabetic rats. Radioreceptor binding assay was done for β₂-adrenoceptors using specific ligand, [³H] propranolol and gene expression studies of β₂-adrenoceptors, transcription factor CREB, insulin receptors and Akt were also done using specific probes. The results of the β₂-adrenoceptor assay showed significant increase in binding parameters, receptor number (B(max)) and equilibrium dissociation constant (K(d)) in the diabetic group in comparison to control. Similarly, an up regulation of β₂-adrenoceptor and CREB gene expression was observed in the diabetic group whereas the insulin receptor expression was down regulated which signifies the increased gly...Continue Reading

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Citations

Dec 10, 2013·European Journal of Pharmacology·Hamid R BanafsheMehdi Shoferpour
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Wei ZhangJun-Li Liu
May 9, 2013·Drug Discovery Today·Vivian SoetiknoKenichi Watanabe
Feb 21, 2014·Journal of Dietary Supplements·Raja LathaPanchanadham Sachdanandam
Dec 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Saori MukaidaMasaaki Sato
Mar 19, 2014·Clinical and Experimental Immunology·C N CastroM J Perone
Jul 14, 2020·Expert Opinion on Investigational Drugs·Sanjay Kumar DeySuman Kundu
Jul 10, 2017·Animal Cells and Systems·Yun-Beom SimHong-Won Suh
Sep 7, 2018·Frontiers in Pharmacology·Aminu Mohammed, Md Shahidul Islam
Jul 17, 2019·Oxidative Medicine and Cellular Longevity·Slavica MutavdzinDragan Djuric

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