PMID: 6111052Jan 1, 1981Paper

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

Neuroscience Letters
J DaviesJ C Watkins

Abstract

A new compound, 2-amino-5-phosphonovaleric acid (2APV) is the most potent and selective N-methyl-D-aspartate (NMDA) receptor antagonist yet tested. As with other compounds of this type, it blocks L-aspartate and dorsal root-evoked excitation of spinal neurons, but is without effect on the cholinergic excitation of Renshaw cells evoked by exogenous acetylcholine or ventral root stimulation. The high potency and selectivity of this compound should prove to be of great value in investigations of the amino acid receptor types involved in synaptic excitation.

References

Nov 24, 1977·Nature·W F WhiteJ T Cummins
Jan 1, 1966·Experimental Brain Research·D R Curtis, R W Ryall
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·J DaviesJ C Watkins
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Citations

Sep 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·W M Landau
Jan 1, 1988·Experimental Brain Research·T Knöpfel, N Dieringer
Jun 1, 1984·Cellular and Molecular Neurobiology·J M ffrench-MullenD O Carpenter
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Jun 1, 1982·Neuropharmacology·H McLennanJ R Liu
Oct 1, 1995·Neuropharmacology·H Mori, M Mishina
Jun 1, 1988·Pharmacology, Biochemistry, and Behavior·D Wirtshafter, R Trifunovic
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·L VelísekP Mares

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