2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

European Journal of Medicinal Chemistry
Renate DetermannConrad Kunick

Abstract

2-Anilino-4-(benzimidazol-2-yl)-pyrimidines, synthesized by reaction of a readily available benzimidazole-substituted enaminone with suitable arylguanidines, were shown to inhibit four cancer-related protein kinases (Aurora B, PLK1, FAK, and VEGF-R2). The most potent derivative exhibited antiproliferative activity for several cancer cell lines of the NCI in vitro cell line panel in submicromolar concentrations. Both the anilinopyrimidine structure and the substitution pattern at the aniline ring appear to be important for the protein kinase inhibitory activity.

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Citations

Apr 25, 2013·Journal of Medicinal Chemistry·Moni SharmaPrem M S Chauhan
May 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina OnnisJan Balzarini
Nov 6, 2018·Chemical Biology & Drug Design·Amany S MostafaMohammad A Elmorsy
Oct 30, 2014·Chemical Biology & Drug Design·Rangappa S KeriBhari Mallanna Nagaraja
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Jing PangSai-Yang Zhang
Aug 4, 2021·Future Medicinal Chemistry·Muhamad MustafaGamal El-Din A Abuo-Rahma
Oct 16, 2020·Journal of Medicinal Chemistry·Yang Lu, Haiying Sun

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