PMID: 11900868Mar 20, 2002Paper

(2-Arylhydrazonomethyl)-substituted xanthones as antimycotics: synthesis and fungistatic activity against Candida species

European Journal of Medicinal Chemistry
Stéphane MoreauAlain Nuhrich

Abstract

A series of arylhydrazones derived from various 6,8-diacetoxy- or 6,8-dihydroxy-9-oxo-9H-xanthene carboxaldehydes were synthesized and evaluated for their in vitro antifungal properties against two human pathogenic yeasts (Candida albicans and C. krusei) according to a diffusion method. The activity was strongly dependent from the position of the (1-arylhydrazinyl-2-ylidene)methyl chain in the xanthone molecular skeleton. Compounds having the nitrogen side chain in the 4-position, with a further halogen substitution on the terminal phenyl ring showed fungistatic effects. Within this series, the 4-fluorophenylhydrazinyl derivative 13g exhibited the highest activity, particularly against C. krusei, with a greater efficacy than that of econazole, used as reference.

References

Oct 1, 1994·Phytochemistry·D C PintoK Hostettmann
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·K V Clemons, D A Stevens
Sep 1, 1996·Phytochemistry·G RathK Hostettmann
Feb 1, 1997·The Journal of Antimicrobial Chemotherapy·D ZakulaR C Goldman
Jul 27, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Bernabeu-WittelA Talegón

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Citations

Apr 29, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Karolina SłoczyńskaHenryk Marona
Nov 17, 2015·SAR and QSAR in Environmental Research·R Medina MarreroF Pérez-Giménez
Oct 24, 2007·European Journal of Medicinal Chemistry·Martine Varache-LembègeAlain Nuhrich
Jul 22, 2008·Bioorganic & Medicinal Chemistry·Henryk MaronaEdward Szneler
Dec 4, 2008·Archiv der Pharmazie·Henryk MaronaEdward Szneler

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