2-Carboxyethylgermanium sesquioxide, a synthetic organogermanium compound, as an inducer of contrasuppressor T cells.

Experientia
K IkemotoF Suzuki

Abstract

2-Carboxyethylgermanium sesquioxide (Ge-132), a synthesized organogermanium compound with immunomodulating activities, was shown to be an inducer of anti-suppressor T cells in normal mice. The suppressor cell activity of T6S cells, a clone of burn-induced CD8+ IL-4-producing suppressor T cells, was clearly inhibited when a mixed lymphocyte-tumor cell reaction of the clone was conducted with splenic mononuclear cells from mice treated orally with a 100 mg/kg dose of Ge-132. The activity of anit-suppressor cells was demonstrated in spleens of mice 2 days after treatment with Ge-132 and reached its peak on day 3. The anti-suppressor cells induced by the compound were of a contrasuppressor T cell-linage, because they were characterized as CD4+ CD28+ TCRalpha/beta+ Vicia villosa lectin-adherent T cells. These cells produced IFN-gamma but did not produce IL-2, IL-4, IL-6 or IL-10 in their culture fluids. CD4+ anti-suppressor T cells induced by Ge-132 may be different from other subsets of CD4+ T cells because Th1 and Th2 cells generated in our laboratory did not adhere to Vicia villosa lectin-coated petri dishes, and each produced specific cytokines. Th1 cells produced IFN-gamma and IL-2 while Th2 cells produce IL-4 and IL-10 in vitr...Continue Reading

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Citations

Jun 1, 2003·Environmental Toxicology and Pharmacology·Silvia GaudenziAgostina Congiu Castellano
May 29, 2004·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Bonnie J KaplanCatherine J Field
Mar 6, 2018·Biological & Pharmaceutical Bulletin·Takeyoshi WadaNaoya Sawamura
Feb 26, 2003·Radiation Research·Shu-Jun ChiuLih-Yuan Lin
May 1, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Alena N KulakovaJoulia Larionova

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