2% chlorhexidine-70% isopropyl alcohol versus 10% povidone-iodine for insertion site cleaning before central line insertion in preterm infants: a randomised trial

Archives of Disease in Childhood. Fetal and Neonatal Edition
Emily A KieranColm Patrick Finbarr O'Donnell

Abstract

To determine whether 2% chlorhexidine gluconate-70% isopropyl alcohol (CHX-IA) is superior to 10% aqueous povidone-iodine (PI) in preventing catheter-related blood stream infection (CR-BSI) when used to clean insertion sites before placing central venous catheters (CVCs) in preterm infants. Randomised controlled trial. Two neonatal intensive care units (NICUs). Infants <31 weeks' gestation who had a CVC inserted. Insertion site was cleaned with CHX-IA or PI. Caregivers were not masked to group assignment. Primary outcome was CR-BSI determined by one microbiologist who was masked to group assignment. Secondary outcomes included skin reactions to study solution and thyroid dysfunction. We enrolled 304 infants (CHX-IA 148 vs PI 156) in whom 815 CVCs (CHX-IA 384 vs PI 431) were inserted and remained in situ for 3078 (CHX-IA 1465 vs PI 1613) days. We found no differences between the groups in the proportion of infants with CR-BSI (CHX-IA 7% vs PI 5%, p=0.631), the proportion of CVCs complicated by CR-BSI or the rate of CR-BSI per 1000 catheter days. Skin reaction rates were low (<1% CVC insertion episodes) and not different between the groups. More infants in the PI group had raised thyroid-stimulating hormone levels and were treate...Continue Reading

References

Jun 9, 1977·The New England Journal of Medicine·D G MakiH W Sarafin
Aug 1, 1992·Journal of Paediatrics and Child Health·A M Watkins, E J Keogh
Mar 1, 1971·American Journal of Diseases of Children·E A Egan, D V Eitzman
Nov 3, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·G WeberG Chiumello
Nov 2, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Carratalà
Jun 5, 2002·Annals of Internal Medicine·Nathorn ChaiyakunaprukSanjay Saint
Jul 2, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·D Hodge, J W L Puntis
Jun 24, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·G Menon
Oct 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·D W Cartwright
Dec 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P R ReynoldsJ H Meek
Mar 8, 2005·Journal of Pediatric Surgery·Minesh KhashuJean-Pierre Chanoine
Apr 17, 2007·American Journal of Infection Control·Sharon E PerlmanElaine L Larson
Apr 27, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Dorothee B BartelsPetra Gastmeier
Jun 26, 2007·Archives of Disease in Childhood·S UpadhyayulaC J Harrison
Oct 24, 2007·Archives of Internal Medicine·Olivier MimozBertrand Debaene
Jun 24, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·M K Datta, P Clarke
Oct 9, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·J S GarlandM C Harris
Jan 8, 2010·The New England Journal of Medicine·Rabih O DarouicheDavid H Berger
Feb 9, 2010·American Journal of Infection Control·Sulaiman SannohBoriana Parvez
Jul 1, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Pranita D TammaAaron M Milstone
Aug 25, 2010·Pediatrics·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Feb 23, 2011·Pediatrics·Joseph SchulmanUNKNOWN New York State Regional Perinatal Care Centers
Apr 29, 2011·American Journal of Infection Control·Naomi P O'GradyUNKNOWN Healthcare Infection Control Practices Advisory Committee
Jul 13, 2011·Archives of Disease in Childhood. Fetal and Neonatal Edition·Harsha Prasada LashkariSunit Godambe
Dec 17, 2011·Archives of Disease in Childhood. Fetal and Neonatal Edition·Vennila PonnusamyPaul Clarke
May 9, 2012·American Journal of Perinatology·Jonathan WongShoo Lee
May 1, 2013·Acta Paediatrica·Dana F J YumaniMirjam M van Weissenbruch
Jul 12, 2013·Journal of Paediatrics and Child Health·Dharmesh Shah, Mark Tracy
Oct 10, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Julie Aitken, Fiona L R Williams
Dec 10, 2013·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Jacqueline E TaylorKenneth Tan
Dec 18, 2013·The Journal of Hospital Infection·H P Loveday UK Department of Health
May 7, 2014·Pediatrics·Anthony GoudieMallikarjuna Rettiganti

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Citations

Jan 27, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Paul Clarke, Mark A Webber
May 22, 2018·The Journal of Perinatal & Neonatal Nursing·Valentina Vanzi, Rosanna Pitaro
Dec 28, 2018·Korean journal of pediatrics·Hye Jung Cho, Hye-Kyung Cho
Oct 1, 2019·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Karen Beekman, Deborah Steward
Feb 26, 2019·The Cochrane Database of Systematic Reviews·Verena WalshWilliam McGuire
Dec 15, 2018·Pediatric Dermatology·Ayan KusariDawn Z Eichenfield
Jun 11, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Akash SharmaMinu Bajpai
Jul 18, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Kim GibsonAdrian Esterman

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