PMID: 6872511Jan 1, 1983Paper

2-Deoxyglucose as a substrate for glutathione regeneration in human and ruminant red blood cells

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
M SuzukiN S Agar

Abstract

2-Deoxyglucose was found to be a substrate for the regeneration of GSH from GSSG in the red blood cells of humans, sheep, goats and cattle. The regeneration rate with 2-deoxyglucose varied from 15 to 56% of the rate with glucose. It is likely that 2-deoxyglucose is phosphorylated to 2-deoxyglucose-6-phosphate by HK and is then oxidized to 2-deoxygluconate-6-phosphate by G6PD. The latter reaction would produce the NADPH required for GSH regeneration.

References

Aug 1, 1978·British Journal of Haematology·T MatsukiY Tani
Mar 10, 1972·Biochemical and Biophysical Research Communications·J W Harris, J E Biaglow
Nov 1, 1974·European Journal of Biochemistry·M F SchmidtC Scholtissek
Nov 6, 1969·Biochemical and Biophysical Research Communications·N S KosowerW S Correa

Citations

Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·N S AgarI D Hume
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·T SuzukiM Suzuki
Dec 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Suzuki, M Kurata
Dec 17, 2009·Journal of Cancer Research and Therapeutics·Andrean L SimonsDouglas R Spitz
Jan 26, 2007·American Journal of Physiology. Cell Physiology·Ahmad AkelFlorian Lang
May 18, 2018·Acta Pharmacologica Sinica·Jing-Si ZhouZheng-Hong Qin
Feb 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·G J SchuurhuisA W Konings
Sep 6, 2020·Biochemical Pharmacology·Clotilde Laussel, Sébastien Léon

Related Concepts

Blood Glucose
Bos indicus
Deoxy Sugars
Deoxyglucose
Erythrocytes
Reduced Glutathione
Goat
Oxidation-Reduction
Dall Sheep

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