PMID: 6872511Jan 1, 1983Paper

2-Deoxyglucose as a substrate for glutathione regeneration in human and ruminant red blood cells

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
M SuzukiN S Agar


2-Deoxyglucose was found to be a substrate for the regeneration of GSH from GSSG in the red blood cells of humans, sheep, goats and cattle. The regeneration rate with 2-deoxyglucose varied from 15 to 56% of the rate with glucose. It is likely that 2-deoxyglucose is phosphorylated to 2-deoxyglucose-6-phosphate by HK and is then oxidized to 2-deoxygluconate-6-phosphate by G6PD. The latter reaction would produce the NADPH required for GSH regeneration.


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