2-Dodecylcyclobutanone does not induce mutations in the Salmonella mutagenicity test or intrachromosomal recombination in Saccharomyces cerevisiae

Journal of Food Protection
Christopher H Sommers, Robert H Schiestl

Abstract

Treatment of foods, such as red meat and poultry, that contain palmitic acid with ionizing radiation leads to the formation of 2-dodecylcyclobutanone (2-DCB), a compound found only in irradiated foods. In this study, the Salmonella mutagenicity test and the yeast DEL assay were used to evaluate the genotoxic potential of 2-DCB. Salmonella Typhimurium tester strains TA98, TA100, TA1535, and TA1537 were exposed to 0, 0.125, 0.25, 0.5, and 1 mg per well of 2-DCB, with and without exogenous metabolic activation (5% S9 fraction), using the microtiter plate-based Miniscreen version of the test. 2-DCB did not induce mutations in the Salmonella mutagenicity test. When Saccharomyces cerevisiae strain RS112, which contains a nonfunctional duplication of the his3 gene that can be induced to form a functional HIS3+ gene by intrachromosomal recombination, was exposed to 0.63, 1.25, 2.5, or 5.0 mg/ml of 2-DCB, no increase in the rate of intrachromosomal (DEL) recombination was observed. The absence of genotoxicity observed in this study using purified 2-DCB agrees with the lack of genotoxic and teratogenic activity observed in previously conducted multigeneration feeding studies of laboratory animals (rats, mice, guinea pigs, and rabbits) th...Continue Reading

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Citations

Jul 23, 2004·The New England Journal of Medicine·Michael McCally, Martin Donohoe
May 9, 2008·Critical Reviews in Food Science and Nutrition·Corliss A O'BryanDennis G Olson
Jun 10, 2017·Journal of Food Science·Angélica B BarbezanAnna Lúcia C H Villavicencio
Aug 18, 2005·Journal of Agricultural and Food Chemistry·Hirotaka ObanaYukio Tanaka
Jun 22, 2006·Journal of Agricultural and Food Chemistry·Priyadarshini Gadgil, J Scott Smith

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