2-[Fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography in the diagnosis of recurrent ovarian cancer

Gynecologic Oncology
M ZimnyU Buell

Abstract

The aim of the study was to investigate the role of 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) in the diagnosis of recurrent ovarian cancer. One hundred six FDG PET scans performed in 54 patients in the follow-up after cytoreductive surgery and chemotherapy of ovarian cancer were reevaluated. Fifty-eight scans were performed in patients with suspected recurrence and 48 scans in patients who were clinically disease free. Thirty-seven PET scans were validated by histology and 66 studies by a median follow-up of 22 months in disease-free patients or 12 months in patients with recurrent disease. Three scans were validated by concordant positive findings of tumor marker CA125, computed tomography, and FDG PET. FDG PET correctly identified recurrent disease in 73/88 cases. PET ruled out recurrent disease in 15/18 cases. The sensitivity and specificity for PET were 83 and 83%, respectively. In patients with suspected disease, sensitivity was 94% compared to 65% in patients judged clinically disease free. The sensitivity of PET was 96% if suspicion of recurrence was based on a rise of CA125 alone. PET preceded the conventional diagnosis by a median of 6 months in patients judged clinically free of d...Continue Reading

References

Feb 15, 1993·Cancer·J T ThigpenT Khansur
Sep 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T SugiyamaH Nishimura
Aug 1, 1996·Nuclear Medicine and Biology·P S ContiJ R Bading
Mar 8, 2000·The Oncologist·M Markman, M A Bookman

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Citations

Feb 7, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E E Kim
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y NakamotoS Fujii
Mar 9, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R SuzukiF Hirahara
Jun 22, 2011·Case Reports in Oncology·Alessandra BernardiAndrea Angelo Martoni
Jan 20, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Harpreet K PannuRichard L Wahl
Oct 18, 2007·Radiology·Daniel J A MargolisSanjiv S Gambhir
Sep 16, 2008·Abdominal Imaging·Anna Maria De GaetanoLorenzo Bonomo
Mar 19, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Hongju SonLale Kostakoglu
Nov 2, 2014·Seminars in Nuclear Medicine·Paul GrantHeather A Jacene
May 17, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Neeraj LalwaniNajla Fasih
Aug 25, 2006·AJR. American Journal of Roentgenology·Eric GontierJean-Louis Alberini
Jul 23, 2004·AJR. American Journal of Roentgenology·William B EubankRobert Livingston
May 17, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C NanniS Fanti
Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F C Muñoz-CasaresA Gómez-Portilla
Sep 17, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Angel ChaoChyong-Huey Lai
Dec 21, 2006·European Journal of Nuclear Medicine and Molecular Imaging·G MangiliF Fazio
Feb 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·María José García-VellosoJosé Angel Richter
Mar 24, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ahmet BiliciMahmut Gumus
Jul 9, 2003·Annals of Nuclear Medicine·Tsuneo SagaJunji Konishi
May 24, 2006·Annals of Nuclear Medicine·Hiromasa KurosakiHirotaka Maruno
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M MurakamiM Ide
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GadducciE Sartori
Oct 21, 2009·Current Oncology Reports·Rebecca A Brooks, Matthew A Powell
Oct 1, 2014·Cancers·Andrea GallaminiAnna Borra
Nov 8, 2015·Annals of Nuclear Medicine·Hyun Jeong KimWon Jun Kang
Mar 12, 2011·European Journal of Radiology·Nishat BharwaniAndrea G Rockall
Dec 20, 2008·Revista española de medicina nuclear·J I Cuenca CuencaR Fernández López
Jun 5, 2007·La Presse médicale·Philippe DebourdeauBernard Colle
Sep 4, 2007·The Lancet Oncology·Tyronne I GoonewardeneGordon J S Rustin
Aug 4, 2009·Seminars in Nuclear Medicine·Dominique DelbekeRichard L Wahl
Mar 26, 2005·Gynecologic Oncology·Laura J HavrileskyEvan R Myers
Oct 20, 2004·Seminars in Nuclear Medicine·Hossein Jadvar, Peter S Conti
Apr 22, 2006·Gynecologic Oncology·Bryony SimcockRodney J Hicks
Jul 30, 2005·Gynecologic Oncology·Robert E BristowRichard L Wahl

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