2'-Functionalized nucleic acids as structural tools in molecular biology

IUBMB Life
Timofei S ZatsepinTatiana S Oretskaya

Abstract

Modified oligonucleotides bearing 2'-reactive groups or 2'-conjugated molecules have found wide application as structural tools in molecular biology. Of principal interest has been the use of 2'-reactive oligonucleotides for cross-linking with biomolecules and of 2'-conjugated oligonucleotides in hybridization assays. In this review we compare a range of electrophilic, nucleophilic and photoreactive groups for cross-linking and conjugation studies.

Citations

Dec 15, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Yu LiuYun-Xing Wang
Mar 1, 2011·Methods : a Companion to Methods in Enzymology·Eduardo ParedesSubha R Das
Dec 29, 2006·Chemistry & Biodiversity·Timofei S ZatsepinTatiana S Oretskaya
Aug 30, 2014·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Hiroyuki AsanumaYukiko Kamiya
Jun 22, 2011·Bioconjugate Chemistry·Le Thi HienTatiana S Oretskaya
Apr 5, 2011·Bioorganicheskaia khimiia·S N Khodyreva, O I Lavrik
Sep 14, 2006·Chemical Reviews·Natarajan Venkatesan, Byeang Hyean Kim

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