2β-hydroxybetulinic acid 3β-caprylate: an active principle from Euryale Ferox Salisb. seeds with antidiabetic, antioxidant, pancreas & hepatoprotective potential in streptozotocin induced diabetic rats

Journal of Food Science and Technology
Danish AhmedAmita Verma

Abstract

The aim of the present study was to evaluate the glycemic control, antioxidant, pancreas and liver protective effect of 2β-hydroxybetulinic acid 3β-caprylate (HBAC) from Euryale ferox Salisb. seeds on streptozotocin induced diabetic rats. The active principle was isolated from Euryale ferox Salisb. seeds extract by utilizing chromatographic techniques. The rats were divided into seven experimental groups: Gp 1-normal; Gp2- normal + HBAC (60 mg/kg p.o.); Gp3- diabetic control; Gp 4- Diabetic + HBAC (20 mg/kg p.o.); Gp5- Diabetic + HBAC (40 mg/kg p.o.); Gp6- Diabetic + HBAC (60 mg/kg p.o.) and Gp 7- Diabetic + Glibenclamide (10 mg/kg p.o.). Biochemical estimation, free radical scavenging examination and histopathological study was performed at the end of experimentation i.e. on 28th day. The active principle isolated and identified with spectral data as 2β-hydroxybetulinic acid 3β-caprylate (HBAC). It was detected for the first time that HBAC has improvised the glycemic control in streptozotocin induced diabetic rats. Furthermore, it is remarkable to note that it exhibited excellent free radical scavenging property and pancreas and hepatoprotective property as well, supported by histopathological examination. One of the mechanism...Continue Reading

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Citations

Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nina I KashchenkoDaniil N Olennikov
Jul 1, 2020·Journal of Biomolecular Structure & Dynamics·Vikas KumarFiroz Anwar
Dec 19, 2020·Toxicon : Official Journal of the International Society on Toxinology·Zong-Yao QianQi-Ming Xian
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Suhair A AbdellatiefShefaa A M El-Mandrawy

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