PMID: 7215349Jan 1, 1981

2-n-nonyl-4-hydroxy[3-3H]quinoline N-oxide: interaction with the mitochondrial membrane

European Journal of Biochemistry
P RiccioE Quagliariello

Abstract

1. Synthesized 2-n-nonyl-4-hydroxy[3-3H]quinoline N-oxide ([3H]NoHOQnO) is a powerful inhibitor of both NADH oxidase and succinate oxidase activities in submitochondrial particles from beef heart. 2. The binding of [3H]NoHOQnO to submitochondrial particles reveals one specific binding site, which is sensitive to antimycin, and a large amount of aspecific binding. 3. The content of [3H]NoHOQnO-specific binding sites is related to the cytochrome b content in the particles. 4. The binding of [3H]NoHOQnO to the specific site causes the inhibition of electron transfer. 5. The relation between the inhibition of NADH oxidation and [3H]NoHOQnO-specific binding is hyperbolic.

References

Aug 23, 1979·Biochimica Et Biophysica Acta·F PalmieriV Iacobazzi
Sep 27, 1976·Biochimica Et Biophysica Acta·J S RIESKE
Jan 6, 1977·Biochimica Et Biophysica Acta·G Van Ark, J A Berden
Dec 7, 1973·Biochimica Et Biophysica Acta·E C Slater
Mar 1, 1974·European Journal of Biochemistry·H G WederP Kesselring
Feb 28, 1972·Biochimica Et Biophysica Acta·J A Berden, E C Slater
Apr 1, 1980·Archives of Biochemistry and Biophysics·H RobertsA W Linnane
May 1, 1956·The Biochemical Journal·J W CORNFORTH, A T JAMES
Oct 17, 1962·Biochemical and Biophysical Research Communications·W S ZAUGG, J S RIESKE

Related Concepts

nonyl-4-hydroxyquinoline-N-oxide
NADH2 oxidase
Antimycin A1
Bos indicus
Cyclic N-Oxides
Respiratory Chain
Chiniofon
Intracellular Membranes
Mitochondria, Heart
Multienzyme Complexes

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