2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy

Biomaterials
Wanyue XiaoXiaochen Dong

Abstract

To overcome irradiation-dependence of cancer phototherapy, a near infrared aza-BODIPY-based photothermogenic photosensitizer BDY with 2-Pyridone group has been synthesized for imaging-guided photothermal synergistic sustainable photodynamic therapy. Multifunctional water-soluble BDY nanoparticles (NPs), with high photothermal conversion efficiency of 35.7% and excellent singlet oxygen (1O2) generation ability, are prepared by self-assembling. The reversible transformation between 2-pyridone moiety and its endoperoxide form endows BDY with continuous 1O2 generation ability under illumination and non-illumination conditions. Simultaneously, BDY NPs exhibit excellent tumor targeting properties by enhanced permeability and retention (EPR) effect and photoacoustic imaging (PAI) ability. Furthermore, the photothermal assisted sustainable photodynamic therapy can significantly inhibit tumor growth (93.4% inhibition) with almost no side effects by intermittent laser illumination. The finding highlights that this photothermal synergistic sustainable phototherapy presents great potential for clinical applications.

Citations

Jul 26, 2019·Angewandte Chemie·Miffy H Y ChengGang Zheng
Jan 8, 2020·Organic & Biomolecular Chemistry·Yuandong ZhangZhigang Xie
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wenhai LinGang Han
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue YangXiaochen Dong
Feb 29, 2020·Photodiagnosis and Photodynamic Therapy·Caixia YiXiao Huang
Feb 26, 2021·Chemical Communications : Chem Comm·Yanqing LiShaohua Wei
Apr 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuan HuangJinjun Shao
Aug 13, 2021·Small·Hanming DaiXiaochen Dong
Oct 16, 2019·Analytical Chemistry·Gongcheng MaJing Lin
May 29, 2020·ACS Applied Materials & Interfaces·Dapeng ChenXiaochen Dong
Jan 16, 2020·Journal of the American Chemical Society·Yan-Qin HePeter J Stang

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