20-HETE requires increased vascular tone to constrict rabbit afferent arterioles

Hypertension
S ArimaK Abe

Abstract

Renal production of 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P-450-dependent arachidonate metabolite, increases during development of hypertension in spontaneously hypertensive rats, and inhibition of its production prevents hypertension. Since 20-HETE is a potent vasoconstrictor, these findings suggest that 20-HETE may contribute to the development of hypertension by elevating renal vascular resistance. In this study we examined the direct action of 20-HETE on the afferent arteriole, a vascular segment crucial to the control of renal vascular resistance. Rabbit afferent arterioles were microperfused at 60 mm Hg in vitro, and 20-HETE was added to the lumen. Although 20-HETE (10(-10) to 10(-6) mol/L) had no effect on the diameter of non-treated afferent arterioles (n=6), it caused dose-dependent constriction when vascular tone was increased with norepinephrine (0.3 micromol/L); 20-HETE at 10(-6) mol/L decreased diameter by 43 +/- 4% (n=6, P < .001). This constriction was abolished by disrupting the endothelium (n=5). Moreover, pretreatment with the cyclooxygenase inhibitor indomethacin (50 micromol/L) or the thromboxane/endoperoxide receptor antagonist SQ29548 (1 micromol/L) significantly (P < .03) attenuated 20-H...Continue Reading

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Citations

Jul 1, 1996·Canadian Journal of Physiology and Pharmacology·P HametJ Tremblay
Oct 26, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K KohaguraS Ito
Mar 19, 2013·Prostaglandins & Other Lipid Mediators·Ying GeRichard J Roman
Mar 17, 2005·The Journal of Pharmacology and Experimental Therapeutics·Adebayo O Oyekan
Jul 11, 2014·American Journal of Physiology. Renal Physiology·Ying GeRichard J Roman
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Sep 14, 1999·The American Journal of Physiology·J C McGiff, J Quilley
Nov 24, 1999·The American Journal of Physiology·R Busse, I Fleming

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