20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet

The British Journal of Nutrition
Gilles FouretChristine Feillet-Coudray

Abstract

The incidence of obesity and its metabolic complications are rapidly increasing and become a major public health issue. This trend is associated with an increase in the prevalence of non-alcoholic fatty liver disease (NAFLD), insulin resistance and diabetes. The sequence of events leading to NAFLD progression and mitochondrial dysfunction and their interrelation remains to be elucidated. This study aimed to explore the installation and progression of NAFLD and its association with the liver mitochondrial structure and activity changes in rats fed an obesogenic diet up to 20 weeks. Male Wistar rats were fed either a standard or high-fat-high-fructose (HFHFR) diet and killed on 4, 8, 12, 16 and 20 weeks of diet intake. Rats fed the HFHFR diet developed mildly overweight, associated with increased adipose tissue weight, hepatic steatosis, hyperglycaemia and hyperinsulinaemia after 8 weeks of HFHFR diet. Hepatic steatosis and many biochemical modifications plateaued at 8-12 weeks of HFHFR diet with slight amelioration afterwards. Interestingly, several biochemical and physiological parameters of mitochondrial function, as well as its phospholipid composition, in particular cardiolipin content, were tightly related to hepatic steato...Continue Reading

References

Jan 1, 1981·Progress in Biophysics and Molecular Biology·P J Quinn
Aug 13, 2002·Journal of Bioenergetics and Biomembranes·Gustavo Barja
Jun 30, 2004·Diabetes & Metabolism·B FromentyD Pessayre
Feb 14, 2006·The British Journal of Nutrition·Marie-Soleil GauthierJean-Marc Lavoie
Aug 11, 2006·American Journal of Physiology. Cell Physiology·Adam J Chicco, Genevieve C Sparagna
Nov 16, 2007·American Journal of Medical Genetics. Part a·Lewis A BarnessEnid Gilbert-Barness
Mar 28, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Eva WarensjöBengt Vessby
Dec 17, 2008·Journal of Lipid Research·Sandra K Erickson
Feb 5, 2009·Biological Research for Nursing·Mary Madeline Rogge
Feb 26, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dian J ChiangLaura E Nagy
Jan 27, 2012·Journal of Physiology and Biochemistry·Mélissa FlammentPierre-Henri Ducluzeau
Apr 12, 2012·Journal of Lipid Research·Santhosh SatapatiShawn C Burgess
Jun 12, 2012·PloS One·Alessandra FerramoscaVincenzo Zara
Mar 30, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bianca M ArendtJohane P Allard
May 22, 2013·Journal of Lipid Research·Irina G StavrovskayaBruce S Kristal
Aug 22, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Joseph D UnsayAna J García-Sáez
Nov 5, 2013·Biochimica Et Biophysica Acta·Giuseppe ParadiesGiuseppe Petrosillo
Nov 13, 2014·Nutrients·Charlotte J Green, Leanne Hodson

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Citations

Jan 29, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fernando Gomez-PinillaLuiz Fernando Freire Royes
Jun 3, 2021·International Journal of Molecular Sciences·Agostino Di CiaulaPiero Portincasa
Jul 3, 2021·International Journal of Molecular Sciences·Inês C M SimõesMariusz R Wieckowski

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