2005 Emil Thomas Kaiser Award.

Protein Science : a Publication of the Protein Society
R T Raines

Abstract

Collagen is the most abundant protein in animals. The conformational stability of the collagen triple helix is enhanced by the hydroxyl group of its prevalent (2S,4R)-4-hydroxyproline residues. For 25 years, the prevailing paradigm had been that this enhanced stability is due to hydrogen bonds mediated by bridging water molecules. We tested this hypothesis with synthetic collagen triple helices containing 4-fluoroproline residues. The results have unveiled a wealth of stereoelectronic effects that contribute markedly to the stability of collagen, as well as other proteins. This new understanding is leading to synthetic collagens for a variety of applications in biotechnology and biomedicine.

References

Jan 1, 1972·Annual Review of Biochemistry·L Brand, J R Gohlke
Sep 1, 1994·International Journal of Peptide and Protein Research·N PanasikR T Raines
Oct 25, 1996·The Journal of Biological Chemistry·M YamashitaT Sakamoto
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·S MoranE T Kool
Feb 12, 1998·Protein Science : a Publication of the Protein Society·E J Milner-White
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Jan 29, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·J Engel, D J Prockop
Feb 18, 1999·Chemistry & Biology·S K HolmgrenR T Raines
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·L FriedmanJ Kimble
Jul 25, 2000·Chemistry & Biology·E Neil, G Marsh
Jul 18, 2001·Journal of the American Chemical Society·L E BretscherR T Raines
Mar 21, 2002·Natural Product Reports·Cara L Jenkins, Ronald T Raines
Dec 21, 2002·Chemical Society Reviews·Nicholas C Yoder, Krishna Kumar
May 23, 2003·Protein Science : a Publication of the Protein Society·Matthew P Hinderaker, Ronald T Raines
Jun 6, 2003·Journal of the American Chemical Society·Cara L JenkinsRonald T Raines
Aug 2, 2003·Journal of the American Chemical Society·Jonathan A Hodges, Ronald T Raines
Dec 4, 2004·The Journal of Organic Chemistry·Cara L JenkinsGrant R Krow
Jun 17, 2005·Organic Letters·Cara L JenkinsRonald T Raines
Nov 10, 2005·Journal of the American Chemical Society·Jonathan A Hodges, Ronald T Raines
Dec 24, 2005·Protein Science : a Publication of the Protein Society·Jia-Cherng Horng, Ronald T Raines
Feb 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Frank W Kotch, Ronald T Raines
Jan 1, 1996·Journal of the American Chemical Society·Eric S EberhardtRonald T Raines

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Citations

Aug 16, 2008·Biochemistry·Kelly L GorresRonald T Raines
Jun 22, 2006·Journal of the American Chemical Society·Matthew D ShouldersRonald T Raines
Aug 5, 2010·Journal of the American Chemical Society·Matthew D ShouldersRonald T Raines
Feb 15, 2008·Journal of the American Chemical Society·Frank W KotchRonald T Raines
Oct 6, 2006·Organic Letters·Jonathan A Hodges, Ronald T Raines
Jan 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Meredith W MillerWilliam F DeGrado
Dec 25, 2010·Nucleic Acids Research·Pradeep S PallanMartin Egli
Apr 7, 2009·Annual Review of Biochemistry·Matthew D Shoulders, Ronald T Raines
Apr 16, 2009·Cellular and Molecular Life Sciences : CMLS·Tse Siang Kang, R Manjunatha Kini
Mar 5, 2010·Critical Reviews in Biochemistry and Molecular Biology·Kelly L Gorres, Ronald T Raines
Dec 5, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·Rita BerisioLuigi Vitagliano
Jul 23, 2015·Journal of Medicinal Chemistry·Eric P GillisNicholas A Meanwell
Jul 7, 2012·The Journal of Physical Chemistry. B·Maria Elisa CrestoniSimonetta Fornarini
Apr 21, 2012·Chemistry : a European Journal·Victoria PeddieAndrew D Abell
Jan 16, 2008·Journal of Computational Chemistry·Villo K Pálfi, András Perczel
Jan 30, 2008·Angewandte Chemie·Sergio A CadamuroLuis Moroder
Jul 2, 2009·Journal of Computational Chemistry·Villo K Pálfi, András Perczel

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