2007 Young Investigator Award: TRP'ing into a new era for glomerular disease.

Journal of the American Society of Nephrology : JASN
Michelle P Winn

Abstract

FSGS is a pathologic lesion that frequently causes the nephrotic syndrome and ensuing renal failure. The cause remains unknown in the majority of individuals; however, in the past two decades, rare familial forms have been identified. It has been suggested that known genetic causes of the hereditary form of this disease account for upwards of 18% of cases. Mutations in five genes have been found to cause inherited nephrotic syndromes and FSGS. In this article, I discuss the phenotypic characteristics of hereditary FSGS and the transient receptor potential cation channel 6 (TRPC6) protein, which is the genetic impetus for an autosomal dominant form of FSGS. The TRP channels have been implicated in varied biologic functions such as mechanosensation, ion homeostasis, cell growth, and phospholipase C-dependent calcium entry into cells. The mutated ion channel causes an increase in calcium transients. Current evidence also suggests that blocking TRPC6 channels may be of therapeutic benefit in idiopathic FSGS, a disease with a generally poor prognosis. Preliminary experiments reveal that the commonly used immunosuppressive agent FK-506 can inhibit TRPC6 activity in vivo. This creates the intriguing possibility that blocking TRPC6 cha...Continue Reading

References

Dec 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F A McCurdyR Wilson
Sep 1, 1980·The American Journal of the Medical Sciences·T NaruseH Kaya
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HaasS Coventry
Jan 1, 1995·American Journal of Nephrology·D J GoodmanJ K Dawborn
Jul 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P J ConlonD N Howell
Jun 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E PedagogosR G Walker
Oct 1, 1994·Kidney International·V D'Agati
Apr 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanV M Buckalew
Jan 15, 1997·The Journal of Clinical Investigation·M E PagtalunanT W Meyer
Dec 9, 1998·Dementia and Geriatric Cognitive Disorders·N L PedersenM Gatz
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B VannierL Birnbaumer
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·L TsiokasV P Sukhatme
Apr 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M P WinnP J Conlon
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·E R LimanC Dulac
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Nov 26, 1999·Kidney International·P J ConlonD N Howell
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Heinrich M RegeleDontscho Kerjaschki
Apr 6, 2000·American Journal of Physiology. Renal Physiology·S J Shankland, G Wolf
Mar 22, 2001·Kidney International·N KambhamV D D'Agati
May 2, 2001·Nature Reviews. Genetics·R M Bush
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Peter Mundel, Stuart J Shankland
Dec 31, 2002·Physiological Reviews·Hermann PavenstädtMatthias Kretzler
Dec 5, 2003·Nature·David E Clapham
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Rainer G RufUNKNOWN Arbeitsgemeinschaft Für Pädiatrische Nephrologie Study Group
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Astrid WeinsMartin R Pollak
Nov 18, 2005·Trends in Molecular Medicine·Wilhelm Kriz
Oct 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Maria A SpassovaDonald L Gill
Nov 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tobias B HuberThomas Benzing
Apr 27, 2007·Biochimica Et Biophysica Acta·Nirvan MukerjiMichelle P Winn

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Citations

Aug 4, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Martin ZenkerCorinne Antignac
Dec 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gianluca CaridiGian Marco Ghiggeri
Nov 27, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rasheed GbadegesinMichelle Winn
Oct 8, 2009·Human Molecular Genetics·Eduardo MachucaCorinne Antignac
Apr 18, 2009·Current Opinion in Nephrology and Hypertension·Peter W Mathieson
May 15, 2013·BMC Nephrology·Amy K MottlKaren E Weck
Jan 9, 2010·Proteomics. Clinical Applications·Bruce A JulianJan Novak
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Alain Meyrier

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